The Journal of Headache and Pain (Apr 2020)
From transformation to chronification of migraine: pathophysiological and clinical aspects
- M. Torres-Ferrús,
- F. Ursitti,
- A. Alpuente-Ruiz,
- F. Brunello,
- D. Chiappino,
- T. de Vries,
- S. Di Marco,
- S. Ferlisi,
- L. Guerritore,
- N. Gonzalez-Garcia,
- A. Gonzalez-Martinez,
- D. Khutorov,
- M. Kritsilis,
- A. Kyrou,
- T. Makeeva,
- A. Minguez-Olaondo,
- L. Pilati,
- A. Serrien,
- O. Tsurkalenko,
- D. Van den Abbeele,
- W. S. van Hoogstraten,
- C. Lampl,
- On behalf of School of Advanced Studies of European Headache Federation (EHF-SAS)
Affiliations
- M. Torres-Ferrús
- Headache and Craniofacial Pain Unit, Neurology Department, Hospital Universitari Vall d’Hebron, Headache and Neurological Pain Research Group, Vall d’Hebron Research Institute (VHIR), Departament de Medicina, Universitat Autònoma de Barcelona
- F. Ursitti
- Headache Center, Child Neurology Unit, Bambino Gesu’ Children’s Hospital
- A. Alpuente-Ruiz
- Headache and Craniofacial Pain Unit, Neurology Department, Hospital Universitari Vall d’Hebron, Headache and Neurological Pain Research Group, Vall d’Hebron Research Institute (VHIR), Departament de Medicina, Universitat Autònoma de Barcelona
- F. Brunello
- Juvenile Headache Centre, Department of Woman’s and Child’s Health, University Hospital of Padua
- D. Chiappino
- Department of Internal medicine, Sant’Andrea Hospital, University of Rome
- T. de Vries
- Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center
- S. Di Marco
- Department of Biomedicine Neuroscience and Advanced Diagnostics, Policlinico Paolo Giaccone Hospital, University of Palermo
- S. Ferlisi
- Department of Biomedicine Neuroscience and Advanced Diagnostics, Policlinico Paolo Giaccone Hospital, University of Palermo
- L. Guerritore
- Department of Internal medicine, Sant’Andrea Hospital, University of Rome
- N. Gonzalez-Garcia
- Headache and Craniofacial Pain Unit, Neurology Department, Hospital Universitario Clínico San Carlos
- A. Gonzalez-Martinez
- Neurology Department, Hospital Universitario de La Princesa & Instituto de Investigación Sanitaria de La Princesa, Universidad Autónoma de Madrid (UAM)
- D. Khutorov
- Department of Clinical Neurology and Sleep Medicine, The Nikiforov Russian Center of Emergency and Radiation Medicine of EMERCOM of Russia
- M. Kritsilis
- Grevena General Hospital
- A. Kyrou
- University Hospital of Psychiatry and Psychotherapy, University of Bern, Switzerland University Hospital of Psychiatry
- T. Makeeva
- Headache Unit, Department of Neurology, Medical center “New Medical Technologies”
- A. Minguez-Olaondo
- Department of Neurology, Universitary Hospital of Donostia
- L. Pilati
- Department of Biomedicine Neuroscience and Advanced Diagnostics, Policlinico Paolo Giaccone Hospital, University of Palermo
- A. Serrien
- Department of Neurology, University Hospitals Leuven
- O. Tsurkalenko
- Department of Neurology and Neurosurgery, State Institution “Dnipropetrovsk medical akademy MOH Ukraine”
- D. Van den Abbeele
- Department of Neurology, Ghent University Hospital
- W. S. van Hoogstraten
- Department of Neuroscience, Erasmus University Medical Centre
- C. Lampl
- Headache Medical Center Linz, Ordensklinikum Linz Barmherzige Schwestern
- On behalf of School of Advanced Studies of European Headache Federation (EHF-SAS)
- DOI
- https://doi.org/10.1186/s10194-020-01111-8
- Journal volume & issue
-
Vol. 21,
no. 1
pp. 1 – 12
Abstract
Abstract Chronic migraine is a neurological disorder characterized by 15 or more headache days per month of which at least 8 days show typical migraine features. The process that describes the development from episodic migraine into chronic migraine is commonly referred to as migraine transformation or chronification. Ample studies have attempted to identify factors associated with migraine transformation from different perspectives. Understanding CM as a pathological brain state with trigeminovascular participation where biological changes occur, we have completed a comprehensive review on the clinical, epidemiological, genetic, molecular, structural, functional, physiological and preclinical evidence available.
Keywords
