Nature Communications (Jun 2021)
Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells
Abstract
Prohibitin 2 can localize to the axon-Schwann-cell interface and is required for myelin formation. Here, the authors show that deletion of prohibitin 1 in Schwann cells instead triggers severe myelin loss likely caused by mitochondrial dysfunction, and not rescued by inhibition of the ensuing integrated stress response.