Nature Communications (Jun 2021)

Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells

  • Gustavo Della-Flora Nunes,
  • Emma R. Wilson,
  • Leandro N. Marziali,
  • Edward Hurley,
  • Nicholas Silvestri,
  • Bin He,
  • Bert W. O’Malley,
  • Bogdan Beirowski,
  • Yannick Poitelon,
  • Lawrence Wrabetz,
  • M. Laura Feltri

DOI
https://doi.org/10.1038/s41467-021-23552-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 16

Abstract

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Prohibitin 2 can localize to the axon-Schwann-cell interface and is required for myelin formation. Here, the authors show that deletion of prohibitin 1 in Schwann cells instead triggers severe myelin loss likely caused by mitochondrial dysfunction, and not rescued by inhibition of the ensuing integrated stress response.