Nature Communications (Jul 2018)

Cell fate potentials and switching kinetics uncovered in a classic bistable genetic switch

  • Xiaona Fang,
  • Qiong Liu,
  • Christopher Bohrer,
  • Zach Hensel,
  • Wei Han,
  • Jin Wang,
  • Jie Xiao

DOI
https://doi.org/10.1038/s41467-018-05071-1
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 9

Abstract

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Bistable switches are a common regulatory motif in cell fate decision-making circuits with two mutually exclusive expression states. Here the authors develop a bistable reporter system and report two additional expression states.