Антибиотики и Химиотерапия (May 2020)

Comparative Study of Antiviral Activity of Luteolin and 7,3’-Disulfate Luteolin

  • N. V. Krylova,
  • A. M. Popov,
  • G. N. Leonova,
  • A. А. Artyukov,
  • O. S. Maistrovskaya

Journal volume & issue
Vol. 56, no. 11-12
pp. 7 – 10

Abstract

Read online

Antiviral activity of 7,3’-disulfate luteolin, extracted from Zostera marina was studied on an experimental model of tick-borne encephalitis (TBE) in vivo and in vitro. The drug increased the survival of the experimental mice infected with TBE virus and prolonged their lifespan. It was shown that 7,3’-disulfate luteolin reduced the virus accumulation in the SPEV cells by 2.0-4.0 lg TCID50/ml.

Keywords