Viruses (Jun 2021)
Previous SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated Individuals
- Benjamin Trinité,
- Edwards Pradenas,
- Silvia Marfil,
- Carla Rovirosa,
- Víctor Urrea,
- Ferran Tarrés-Freixas,
- Raquel Ortiz,
- Jordi Rodon,
- Júlia Vergara-Alert,
- Joaquim Segalés,
- Victor Guallar,
- Rosalba Lepore,
- Nuria Izquierdo-Useros,
- Glòria Trujillo,
- Jaume Trapé,
- Carolina González-Fernández,
- Antonia Flor,
- Rafel Pérez-Vidal,
- Ruth Toledo,
- Anna Chamorro,
- Roger Paredes,
- Ignacio Blanco,
- Eulàlia Grau,
- Marta Massanella,
- Jorge Carrillo,
- Bonaventura Clotet,
- Julià Blanco
Affiliations
- Benjamin Trinité
- IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Autonomous University of Barcelona (UAB), 08916 Badalona, Spain
- Edwards Pradenas
- IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Autonomous University of Barcelona (UAB), 08916 Badalona, Spain
- Silvia Marfil
- IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Autonomous University of Barcelona (UAB), 08916 Badalona, Spain
- Carla Rovirosa
- IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Autonomous University of Barcelona (UAB), 08916 Badalona, Spain
- Víctor Urrea
- IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Autonomous University of Barcelona (UAB), 08916 Badalona, Spain
- Ferran Tarrés-Freixas
- IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Autonomous University of Barcelona (UAB), 08916 Badalona, Spain
- Raquel Ortiz
- IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Autonomous University of Barcelona (UAB), 08916 Badalona, Spain
- Jordi Rodon
- Institute de Recerca i Tecnologia Agrària (IRTA), Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, 08193 Bellaterra, Spain
- Júlia Vergara-Alert
- Institute de Recerca i Tecnologia Agrària (IRTA), Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, 08193 Bellaterra, Spain
- Joaquim Segalés
- Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, Autonomous University of Barcelona (UAB), 08193 Bellaterra, Spain
- Victor Guallar
- Barcelona Supercomputing Center, 08034 Barcelona, Spain
- Rosalba Lepore
- Barcelona Supercomputing Center, 08034 Barcelona, Spain
- Nuria Izquierdo-Useros
- IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Autonomous University of Barcelona (UAB), 08916 Badalona, Spain
- Glòria Trujillo
- Fundació Althaia, Hospital de Sant Joan de Déu, 08243 Manresa, Spain
- Jaume Trapé
- Fundació Althaia, Hospital de Sant Joan de Déu, 08243 Manresa, Spain
- Carolina González-Fernández
- Fundació Althaia, Hospital de Sant Joan de Déu, 08243 Manresa, Spain
- Antonia Flor
- Fundació Althaia, Hospital de Sant Joan de Déu, 08243 Manresa, Spain
- Rafel Pérez-Vidal
- Fundació Althaia, Hospital de Sant Joan de Déu, 08243 Manresa, Spain
- Ruth Toledo
- Infectious Diseases Department, Fight against AIDS Foundation (FLS), Germans Trias i Pujol Hospital, 08916 Badalona, Spain
- Anna Chamorro
- Infectious Diseases Department, Fight against AIDS Foundation (FLS), Germans Trias i Pujol Hospital, 08916 Badalona, Spain
- Roger Paredes
- IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Autonomous University of Barcelona (UAB), 08916 Badalona, Spain
- Ignacio Blanco
- Germans Trias i Pujol Hospital, 08916 Badalona, Spain
- Eulàlia Grau
- IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Autonomous University of Barcelona (UAB), 08916 Badalona, Spain
- Marta Massanella
- IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Autonomous University of Barcelona (UAB), 08916 Badalona, Spain
- Jorge Carrillo
- IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Autonomous University of Barcelona (UAB), 08916 Badalona, Spain
- Bonaventura Clotet
- IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Autonomous University of Barcelona (UAB), 08916 Badalona, Spain
- Julià Blanco
- IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, Autonomous University of Barcelona (UAB), 08916 Badalona, Spain
- DOI
- https://doi.org/10.3390/v13061135
- Journal volume & issue
-
Vol. 13,
no. 6
p. 1135
Abstract
With the spread of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is a need to assess the protection conferred by both previous infections and current vaccination. Here we tested the neutralizing activity of infected and/or vaccinated individuals against pseudoviruses expressing the spike of the original SARS-CoV-2 isolate Wuhan-Hu-1 (WH1), the D614G mutant and the B.1.1.7 variant. Our data show that parameters of natural infection (time from infection and nature of the infecting variant) determined cross-neutralization. Uninfected vaccinees showed a small reduction in neutralization against the B.1.1.7 variant compared to both the WH1 strain and the D614G mutant. Interestingly, upon vaccination, previously infected individuals developed more robust neutralizing responses against B.1.1.7, suggesting that vaccines can boost the neutralization breadth conferred by natural infection.
Keywords
