Advances in the Study of Non-Coding RNA in the Signaling Pathway of Pulmonary Fibrosis

Abstract

Dengyun Pan, Xin Di, Bingdi Yan, Xiaomin Su Department of Respiratory Medicine, The Second Hospital of Jilin University, Changchun, People’s Republic of ChinaCorrespondence: Bingdi Yan; Xiaomin Su, Department of Respiratory Medicine, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun, 130041, People’s Republic of China, Email [email protected]; [email protected]: Pulmonary fibrosis is a group of chronic, progressive, and irreversible interstitial lung diseases, which are common to most end-stage lung diseases and are one of the most difficult diseases of the respiratory system. In recent years, due to the frequent occurrence of air pollution and smog, the incidence of pulmonary fibrosis in China has increased year by year, the morbidity and mortality rates of pulmonary fibrosis have gradually increased and the age of the disease tends to be younger. However, the pathogenesis of pulmonary fibrosis is not yet fully understood and is needed to further explore new drug targets. Studies have shown that non-coding RNAs play an important role in regulating the process of pulmonary fibrosis, non-coding RNAs and their specifically expressed can promote or inhibit the process. Here, we review the role of some in the regulation of pulmonary fibrosis signaling pathways and provide new ideas for the clinical diagnosis and treatment of pulmonary fibrosis.Keywords: pulmonary fibrosis, MicroRNA, LncRNA, CircRNA, signaling pathways

Keywords

• pulmonary fibrosis
• microrna
• lncrna
• circrna
• signaling pathways