Dynamic analysis of serum markers of HBV in 302 infants of pregnant women with HBV infection

Abstract

Objective To investigate the dynamic changes of HBV serum markers (HBV-M) in pregnant women with HBV infection and its clinical significance. Methods A total of 302 infants delivered by HBV infected pregnant women registered and examined in our hospital from January 2016 to April 2020 were included. Serum HBV-M and HBV-DNA were detected in the 302 pregnant women during late pregnancy and in their infants aged 6~12 months (time point 1, T1) and 20~30 months (time point 2, T2). The dynamic changes and influencing factors were analyzed. Results For the infants, HBsAg was negative at both time points, and there were 301 cases of anti-HBs positive, 3 cases of HBeAg positive, 46 cases of anti-HBe positive and 207 cases of anti-HBc positive at T1, and all these indicators were decreased gradually with the age of infants. At T2, 8 cases of anti-HBs positive turned negative, while those of HBeAg, anti-HBe and anti-HBc positive turned negative. The lower the titer of T1 anti-HBs was, the more likely it was to turn negative. At T2, the titer of anti-HBs was not related to feeding mode, delivery mode and mother HBV DNA level. Conclusion Serum HBeAg, anti-HBe and anti-HBc are all derived from the mother and metabolized gradually. The success rate of mother-to-child prevention for HBV infected pregnant women is quite high. If the titer of the initial test is relatively low, the time of reexamination should be shortened.

Keywords

• hepatitis b virus
• serological markers
• mother-to-child transmission