Ginkgo biloba extract-loaded PLGA microcapsules generated from microfluidics for Alzheimer's disease treatment

Xiao Zhang; Weina Yao; Huijuan Zhou; Huan Wang; Bin Kong; Feng Bai

Materials & Design (Feb 2024)

Ginkgo biloba extract-loaded PLGA microcapsules generated from microfluidics for Alzheimer's disease treatment

Xiao Zhang,
Weina Yao,
Huijuan Zhou,
Huan Wang,
Bin Kong,
Feng Bai

Affiliations

Xiao Zhang: Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210008, China
Weina Yao: Department of Neurology, Taikang Xianlin Drum Tower Hospital Clinical College of Wuhan University, Nanjing 210046, China
Huijuan Zhou: Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210008, China
Huan Wang: The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518033, China; Corresponding authors at: Geriatric Medicine Center, Taikang Xianlin Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, China (F. Bai); Department of Neurology, Taikang Xianlin Drum Tower Hospital Clinical College of Wuhan University, China (H. Wang).
Bin Kong: Department of Neurosurgery, Health Science Center, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, Guangdong 518035, China; Corresponding authors at: Geriatric Medicine Center, Taikang Xianlin Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, China (F. Bai); Department of Neurology, Taikang Xianlin Drum Tower Hospital Clinical College of Wuhan University, China (H. Wang).
Feng Bai: Geriatric Medicine Center, Taikang Xianlin Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210046, China; Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China; Institute of Geriatric Medicine, Medical School of Nanjing University, Nanjing 210008, China; Corresponding authors at: Geriatric Medicine Center, Taikang Xianlin Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, China (F. Bai); Department of Neurology, Taikang Xianlin Drum Tower Hospital Clinical College of Wuhan University, China (H. Wang).

Journal volume & issue: Vol. 238
p. 112735

Abstract

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Boosting the birth rate of new neurons in the adult hippocampus is a possible treatment method for the management of Alzheimer's disease (AD). Recent studies have revealed that Ginkgo biloba extract (GBE) can act as a neuroprotective agent to prevent memory loss in a variety of neurodegenerative illnesses. However, the low bioavailability and short half-life of active components in vivo limit their application. Here, we describe a class of microcapsules (MPs) for sustained GBE delivery that have gelatin methacrylate (GelMa) cores and poly(L-lactide-co-glycolide) (PLGA) shells. The encapsulated GBE was slowly released from the solidified MPs during degradation of the polymer. In addition, the MPs showed good biocompatibility in cell experiments. When GelMa-PLGA MPs containing GBE were applied to APP/PS1 mice, amyloid deposition in the mouse brain was reduced, and cognitive impairment was improved. These results indicate that GBE-encapsulated MPs have potential clinical value in treating AD and other neurodegenerative diseases.

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

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