6.5 ASSOCIATION BETWEEN INCREASED ARTERIAL STIFFNESS AND HBA1C AND LDL CHOLESTEROL LEVEL IN TYPE 2 DIABETES PATIENTS

Abstract

Background: In patient with type 2 diabetes mellitus (T2DM) the atherosclerosis apper in younger age, in both gender and the cardiovascular risk is much higher. The aim of our study was to examine the association between pulse wave velocity (PWV) and glycated haemoglobin (HbA1c) and low density lipoprotein (LDL-C) level in patient with T2DM. (1,2) Methods: We performed a prospective observational study, outpatient measurement included: aorta PWV measured by arteriograph, HbA1c and LDL-C level. The cut off-points are: PWV: 9 m/s, LDL-C: 2,5 mmol/l, HbA1c: 6%. In the first part of the analysis were included 169 patients with T2DM (106 men, 63 women, average age: 59 year), and were 152 patients (99 men, 53 women, average age: 59 year) in the second part. Linear regression analysis was carried using SPSS software.Values of p<0.05 were considered to be statistically significant. Results: In the first investigation we found signicantly higher PWV in 87 patients (51%), mean: 9,27 m/s. The LDL-C level was higher than 2,5 mmol/l in 67% of cases, mean: 2,935 mmol/l. The second investigation underline a strict linear association between PWV and HbA1c (means: PWV: 9,286 m/s, HbA1c: 6,792 %.) Conclusion: Our studies show parallel association between elevated HbA1c and PWV, as well as between higher LDL-C and PWV, which represent the elevated arterial stiffness (AS). Measurement of arterial stiffness can provide additional information about cardiovascular risk in patient with T2DM, which support the importance of arteriograph the only type of non-invasive method for AS measurement. (3,4)