Nature Communications (Nov 2020)

Development of a multi-antigenic SARS-CoV-2 vaccine candidate using a synthetic poxvirus platform

  • Flavia Chiuppesi,
  • Marcela d’Alincourt Salazar,
  • Heidi Contreras,
  • Vu H. Nguyen,
  • Joy Martinez,
  • Yoonsuh Park,
  • Jenny Nguyen,
  • Mindy Kha,
  • Angelina Iniguez,
  • Qiao Zhou,
  • Teodora Kaltcheva,
  • Roman Levytskyy,
  • Nancy D. Ebelt,
  • Tae Hyuk Kang,
  • Xiwei Wu,
  • Thomas F. Rogers,
  • Edwin R. Manuel,
  • Yuriy Shostak,
  • Don J. Diamond,
  • Felix Wussow

DOI
https://doi.org/10.1038/s41467-020-19819-1
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

Read online

Chiuppesi et al. demonstrate the use of a synthetic poxvirus-based platform to rapidly generate multi-antigenic vaccine candidates expressing spike and nucleocapsid antigens of SARS-CoV-2. Immunization of mice stimulates potent antigen-specific humoral and cellular immune responses, including neutralizing antibodies.