Frontiers in Neurology (Aug 2020)
Motor and Sensory Features of Cervical Dystonia Subtypes: Data From the Italian Dystonia Registry
- Francesca Di Biasio,
- Roberta Marchese,
- Giovanni Abbruzzese,
- Ottavia Baldi,
- Marcello Esposito,
- Francesco Silvestre,
- Girolamo Tescione,
- Alfredo Berardelli,
- Alfredo Berardelli,
- Giovanni Fabbrini,
- Giovanni Fabbrini,
- Gina Ferrazzano,
- Roberta Pellicciari,
- Roberto Eleopra,
- Grazia Devigili,
- Francesco Bono,
- Domenico Santangelo,
- Laura Bertolasi,
- Maria Concetta Altavista,
- Vincenzo Moschella,
- Paolo Barone,
- Roberto Erro,
- Alberto Albanese,
- Cesa Scaglione,
- Rocco Liguori,
- Maria Sofia Cotelli,
- Giovanni Cossu,
- Roberto Ceravolo,
- Mario Coletti Moja,
- Maurizio Zibetti,
- Antonio Pisani,
- Martina Petracca,
- Martina Petracca,
- Michele Tinazzi,
- Luca Maderna,
- Paolo Girlanda,
- Luca Magistrelli,
- Luca Magistrelli,
- Salvatore Misceo,
- Marcello Romano,
- Brigida Minafra,
- Nicola Modugno,
- Marco Aguggia,
- Daniela Cassano,
- Giovanni Defazio,
- Laura Avanzino,
- Laura Avanzino
Affiliations
- Francesca Di Biasio
- IRCCS Policlinico San Martino, Genoa, Italy
- Roberta Marchese
- IRCCS Policlinico San Martino, Genoa, Italy
- Giovanni Abbruzzese
- Department of Neuroscience, Rehabilitation, Ophtalmology, Genetics and Maternal Child Health, University of Genoa, Genoa, Italy
- Ottavia Baldi
- Department of Neuroscience, Rehabilitation, Ophtalmology, Genetics and Maternal Child Health, University of Genoa, Genoa, Italy
- Marcello Esposito
- Department of Neurosciences, Reproductive Sciences and Odontostomatology, Federico II University of Naples, Naples, Italy
- Francesco Silvestre
- Department of Neurosciences, Reproductive Sciences and Odontostomatology, Federico II University of Naples, Naples, Italy
- Girolamo Tescione
- “Salvatore Maugeri” Foundation, Institute of Telese Terme (BN), Benevento, Italy
- Alfredo Berardelli
- Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy
- Alfredo Berardelli
- IRCSS Neuromed, Pozzilli, Italy
- Giovanni Fabbrini
- Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy
- Giovanni Fabbrini
- IRCSS Neuromed, Pozzilli, Italy
- Gina Ferrazzano
- Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy
- Roberta Pellicciari
- Department of Basic Science, Neuroscience and Sense Organs, Aldo Moro University of Bari, Bari, Italy
- Roberto Eleopra
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta, UOC Neurologia 1, Milan, Italy
- Grazia Devigili
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta, UOC Neurologia 1, Milan, Italy
- Francesco Bono
- Neurology Unit, Center for Botulinum Toxin Therapy, A.O.U. Mater Domini, Catanzaro, Italy
- Domenico Santangelo
- Neurology Unit, Center for Botulinum Toxin Therapy, A.O.U. Mater Domini, Catanzaro, Italy
- Laura Bertolasi
- 0Neurologic Unit, University Hospital, Verona, Italy
- Maria Concetta Altavista
- 1San Filippo Neri Hospital, ASL Roma 1, Rome, Italy
- Vincenzo Moschella
- 1San Filippo Neri Hospital, ASL Roma 1, Rome, Italy
- Paolo Barone
- 2Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, Neuroscience Section, Universitá di Salerno, Baronissi, Italy
- Roberto Erro
- 2Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, Neuroscience Section, Universitá di Salerno, Baronissi, Italy
- Alberto Albanese
- 3IRCCS Humanitas Research Hospital Humanitas, Milan, Italy
- Cesa Scaglione
- 4IRCCS Institute of Neurological Sciences, Bologna, Italy
- Rocco Liguori
- 4IRCCS Institute of Neurological Sciences, Bologna, Italy
- Maria Sofia Cotelli
- 5Neurology Unit, ASST Valcamonica, Esine, Italy
- Giovanni Cossu
- 6Neurology Service and Stroke Unit, Department of Neuroscience, AO Brotzu, Cagliari, Italy
- Roberto Ceravolo
- 7Neurology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
- Mario Coletti Moja
- 8Neurology Unit, Umberto I Hospital, Turin, Italy
- Maurizio Zibetti
- 9Department of Neuroscience 'Rita Levi Montalcini', University of Turin, Turin, Italy
- Antonio Pisani
- 0Neurology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
- Martina Petracca
- 1Fondazione Policlinico Universitario A. Gemelli – IRCCS, Rome, Italy
- Martina Petracca
- 2Institute of Neurology, Università Cattolica del Sacro Cuore, Rome, Italy
- Michele Tinazzi
- 3Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy
- Luca Maderna
- 4Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy
- Paolo Girlanda
- 5Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
- Luca Magistrelli
- 6Movement Disorders Centre, Neurology Unit, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy
- Luca Magistrelli
- 7PhD Program in Clinical and Experimental Medicine and Medical Humanities, University of Insubria, Varese, Italy
- Salvatore Misceo
- 8Neurologic Unit, San Paolo Hospital, Bari, Italy
- Marcello Romano
- 9Neurology Unit AOOR Villa Sofia Cervello, Palermo, Italy
- Brigida Minafra
- 0Parkinson's Disease and Movement Disorders Unit, IRCCS Mondino Foundation, Pavia, Italy
- Nicola Modugno
- IRCSS Neuromed, Pozzilli, Italy
- Marco Aguggia
- 1Neurology Department, Asti Hospital, Asti, Italy
- Daniela Cassano
- 2Unit of Neurology, Ospedale Maria Vittoria, Turin, Italy
- Giovanni Defazio
- 3Neurology Unit, Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy
- Laura Avanzino
- IRCCS Policlinico San Martino, Genoa, Italy
- Laura Avanzino
- 4Department of Experimental Medicine, Section of Human Physiology, University of Genoa, Genoa, Italy
- DOI
- https://doi.org/10.3389/fneur.2020.00906
- Journal volume & issue
-
Vol. 11
Abstract
Introduction: Cervical dystonia (CD) is one of the most common forms of adult-onset isolated dystonia. Recently, CD has been classified according to the site of onset and spread, in different clinical subgroups, that may represent different clinical entities or pathophysiologic subtypes. In order to support this hypothesis, in this study we have evaluated whether different subgroups of CD, that clinically differ for site of onset and spread, also imply different sensorimotor features.Methods: Clinical and demographic data from 842 patients with CD from the Italian Dystonia Registry were examined. Motor features (head tremor and tremor elsewhere) and sensory features (sensory trick and neck pain) were investigated. We analyzed possible associations between motor and sensory features in CD subgroups [focal neck onset, no spread (FNO-NS); focal neck onset, segmental spread (FNO-SS); focal onset elsewhere with segmental spread to neck (FOE-SS); segmental neck involvement without spread (SNI)].Results: In FNO-NS, FOE-SS, and SNI subgroups, head tremor was associated with the presence of tremor elsewhere. Sensory trick was associated with pain in patients with FNO-NS and with head tremor in patients with FNO-SS.Conclusion: The frequent association between head tremor and tremor elsewhere may suggest a common pathophysiological mechanism. Two mechanisms may be hypothesized for sensory trick: a gating mechanism attempting to reduce pain and a sensorimotor mechanism attempting to control tremor.
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