A STUDY OF SERUM LACTATE AS A PREDICTOR OF SEVERITY IN DENGUE INFECTION

Abstract

Background: Dengue infections caused by the four antigenically distinct dengue virus serotypes (DENV1, DENV2, DENV3, DENV4) of the family Flaviviridae are the most major arboviral diseases in humans in terms of geographic spread, morbidity, and mortality. Objective: serum lactate as a predictor of severity in dengue infection Methodology: A prospective observational study was carried out among indoor patients admitted to the general medicine department of the tertiary care hospital SMIMER Surat. The study's duration was 15 to 18 months. Result: our study found out of a total of 154 cases, the majority of cases belonged to 83(53.90%) cases were from less than 30 years. the male contributed 96 (62.34%), the majority of cases had a duration of fever 39(25.32%), 66 (42.66%) cases had high LDH, comparison of serum lactate dehydrogenase with the severity of dengue mean lactate dehydrogenase of dengue without severity was mean was 148.45 and SD 11.81, while in severe dengue mean serum lactate dehydrogenase 388.23 and SD 99.47 with p value 0.001 which was statically significant. Conclusion: According to this study, it is preferable to monitor serial lactate levels as opposed to using a single lactate number.

Keywords

• Dengue
• Dengue hemorrhagic fever (DHF)
• Dengue shock syndrome (DSS)
• Lactate dehydrogenase (LDH)