Role of targeted therapy in the treatment of HER-2-positive breast cancer brain metastases

G. A. Dashyan; V. F. Semiglazov; P. V. Krivorot’ko; T. Yu. Semiglazova; E. E. Topuzov; R. M. Paltuev; K. Yu. Zernov; V. S. Apollonova; S. S. Ereshchenko; A. V. Petrova; E. K. Zhil’tsova; O. A. Ivanova

doi:10.17650/1994-4098-2016-12-1-46-51

Опухоли женской репродуктивной системы (Jun 2016)

Role of targeted therapy in the treatment of HER-2-positive breast cancer brain metastases

G. A. Dashyan,
V. F. Semiglazov,
P. V. Krivorot’ko,
T. Yu. Semiglazova,
E. E. Topuzov,
R. M. Paltuev,
K. Yu. Zernov,
V. S. Apollonova,
S. S. Ereshchenko,
A. V. Petrova,
E. K. Zhil’tsova,
O. A. Ivanova

Affiliations

G. A. Dashyan: N.N. Petrov Research Institute of Oncology, Ministry of Health of Russia; 68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg, 197758, Russia
V. F. Semiglazov: N.N. Petrov Research Institute of Oncology, Ministry of Health of Russia; 68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg, 197758, Russia
P. V. Krivorot’ko: N.N. Petrov Research Institute of Oncology, Ministry of Health of Russia; 68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg, 197758, Russia
T. Yu. Semiglazova: N.N. Petrov Research Institute of Oncology, Ministry of Health of Russia; 68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg, 197758, Russia
E. E. Topuzov: I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia; 41 Kirochnaya St., Saint Petersburg, 191015, Russia
R. M. Paltuev: N.N. Petrov Research Institute of Oncology, Ministry of Health of Russia; 68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg, 197758, Russia
K. Yu. Zernov: N.N. Petrov Research Institute of Oncology, Ministry of Health of Russia; 68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg, 197758, Russia
V. S. Apollonova: N.N. Petrov Research Institute of Oncology, Ministry of Health of Russia; 68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg, 197758, Russia
S. S. Ereshchenko: N.N. Petrov Research Institute of Oncology, Ministry of Health of Russia; 68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg, 197758, Russia
A. V. Petrova: N.N. Petrov Research Institute of Oncology, Ministry of Health of Russia; 68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg, 197758, Russia
E. K. Zhil’tsova: N.N. Petrov Research Institute of Oncology, Ministry of Health of Russia; 68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg, 197758, Russia
O. A. Ivanova: N.N. Petrov Research Institute of Oncology, Ministry of Health of Russia; 68 Leningradskaya St., Pesochnyi Settlement, Saint Petersburg, 197758, Russia

DOI: https://doi.org/10.17650/1994-4098-2016-12-1-46-51
Journal volume & issue: Vol. 12, no. 1
pp. 46 – 51

Abstract

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Brain metastases are detectable in 25–35 % of patients with progressive HER-2-positve breast cancer. Even after spreading metastases into the brain, chemotherapy in combination with anti-HER- 2 therapy improves survival due to better control of the systemic disease. The paper presents the results of investigations substantiating the use of anti-HER-2 targeting agents, as well as the innovative agent T-DM1 to treat brain metastases.

Published in Опухоли женской репродуктивной системы

ISSN: 1994-4098 (Print); 1999-8627 (Online)
Publisher: ABV-press
Country of publisher: Russian Federation
LCC subjects: Medicine: Gynecology and obstetrics
Website: http://ojrs.abvpress.ru/

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