Acta Biomedica Scientifica (May 2018)
The -141c Ins/Del polymorphism of the D<sub>2</sub>-dopaminergic receptor gene as a marker of early development of essential arterial hypertension in adolescents
Abstract
Background. The relevance of the search for genetic markers of essential hypertension (EH), is beyond doubt. The importance of research of dopaminergic system genes consists primarily of pleiotropic effects of dopamine on different systems and functions of the body. The aim of this study was to identify the association of polymorphism -141C 1/D D2-dopaminergic receptor (DRD2) with parameters of psycho-vegetative status and cardiovascular system indicators in adolescents with EH. Methods. We carried out an investigation of 14-17-year old (15.92 ± 1.12) Caucasian male patients with EH (n = 110) in clinic of Scientific Centre for Family Health and Human Reproduction Problems. Psychological testing, clinoorthostatic test, ambulatory blood pressure monitoring (ABPM), and genotyping have been carried. Results. 11-genotype is associated with higher «hypomania» personality traits (scale 9 of Mini-SMIL was 4.2 (4-5) in carriers of the 11-genotype and 4.0 (3-4) in 1D and DD-genotype carriers, p = 0.024), asthenosympathicotonic variant of autonomic support and pressure load (ejection fraction in carriers of the 11-genotype was 71.47 ± 5.98 % and 68.44 ± 6.01 % in 1D and DD-genotype carriers, p = 0.044, time of systolic blood pressure hypertension in carriers of the 11-genotype - 35.50 (20.5-51.5) and 18.30 (6.5-32) - in 1D and DD-genotype carriers, p = 0.010, the time of diastolic blood pressure hypertension in 11-genotype carriers was 13 (7.85-26.5) and 2 (0.9-11) - in 1D and DD-genotype carriers, p = 0,002). Conclusion. -141C I/D DRD2 polymorphism is associated with disorders of important indicators of psycho-vegetative status and cardiovascular system, including circadian organization of blood pressure, which allows considering it as a marker of early development of EH in adolescents.
Keywords
