Nature Communications (Aug 2016)

Metal-responsive promoter DNA compaction by the ferric uptake regulator

  • Davide Roncarati,
  • Simone Pelliciari,
  • Nicola Doniselli,
  • Stefano Maggi,
  • Andrea Vannini,
  • Luca Valzania,
  • Luca Mazzei,
  • Barbara Zambelli,
  • Claudio Rivetti,
  • Alberto Danielli

DOI
https://doi.org/10.1038/ncomms12593
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 13

Abstract

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The Fur protein regulates transcription of bacterial genes in response to metal ions. Here, the authors show that the Fur protein from Helicobacter pylorirepresses transcription by iron-responsive oligomerization and DNA compaction, encasing the transcriptional start site in a macromolecular complex.