The functions and mechanisms of RNA modification in prostate: Current status and future perspectives

Zhijin Zhang; Zhijin Zhang; Ji Liu; Ji Liu; Yang Wu; Zhuoran Gu; Zhuoran Gu; Libin Zou; Libin Zou; Yingdi Liu; Jiang Geng; Jiang Geng; Shiyu Mao; Shiyu Mao; Ming Luo; Ming Luo; Changcheng Guo; Changcheng Guo; Wentao Zhang; Wentao Zhang; Xudong Yao; Xudong Yao

doi:10.3389/fgene.2024.1380746

Frontiers in Genetics (May 2024)

The functions and mechanisms of RNA modification in prostate: Current status and future perspectives

Zhijin Zhang,
Zhijin Zhang,
Ji Liu,
Ji Liu,
Yang Wu,
Zhuoran Gu,
Zhuoran Gu,
Libin Zou,
Libin Zou,
Yingdi Liu,
Jiang Geng,
Jiang Geng,
Shiyu Mao,
Shiyu Mao,
Ming Luo,
Ming Luo,
Changcheng Guo,
Changcheng Guo,
Wentao Zhang,
Wentao Zhang,
Xudong Yao,
Xudong Yao

Affiliations

Zhijin Zhang: Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
Zhijin Zhang: Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
Ji Liu: Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
Ji Liu: Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
Yang Wu: School of Medicine, Tongji University, Shanghai, China
Zhuoran Gu: Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
Zhuoran Gu: Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
Libin Zou: Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
Libin Zou: Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
Yingdi Liu: Department of Pathology, Shanghai Tenth People’s Hospital, Shanghai, China
Jiang Geng: Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
Jiang Geng: Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
Shiyu Mao: Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
Shiyu Mao: Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
Ming Luo: Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
Ming Luo: Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
Changcheng Guo: Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
Changcheng Guo: Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
Wentao Zhang: Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
Wentao Zhang: Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
Xudong Yao: Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
Xudong Yao: Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China

DOI: https://doi.org/10.3389/fgene.2024.1380746
Journal volume & issue: Vol. 15

Abstract

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The increasing incidence and mortality of prostate cancer worldwide significantly impact the life span of male patients, emphasizing the urgency of understanding its pathogenic mechanism and associated molecular changes that regulate tumor progression for effective prevention and treatment. RNA modification, an important post-transcriptional regulatory process, profoundly influences tumor cell growth and metabolism, shaping cell fate. Over 170 RNA modification methods are known, with prominent research focusing on N6-methyladenosine, N7-methylguanosine, N1-methyladenosine, 5-methylcytidine, pseudouridine, and N4-acetylcytidine modifications. These alterations intricately regulate coding and non-coding RNA post-transcriptionally, affecting the stability of RNA and protein expression levels. This article delves into the latest advancements and challenges associated with various RNA modifications in prostate cancer tumor cells, tumor microenvironment, and core signaling molecule androgen receptors. It aims to provide new research targets and avenues for molecular diagnosis, treatment strategies, and improvement of the prognosis in prostate cancer.

Published in Frontiers in Genetics

ISSN: 1664-8021 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General): Genetics
Website: http://journal.frontiersin.org/journal/genetics

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