Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology
James N. Tsoporis,
Ioannis-Alexandros Drosatos,
Sahil Gupta,
Hajera Amatullah,
Shehla Izhar,
Claudia C. dos Santos,
Vasileos Salpeas,
Angelos G. Rigopoulos,
Ioannis K. Toumpoulis,
Andreas S. Triantafyllis,
Eleftharios Sakadakis,
Nikolaos Kavantzas,
John C. Marshall,
Ioannis K. Rizos,
Thomas G. Parker
Affiliations
James N. Tsoporis
Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, University of Toronto, Toronto, ON M5B 1W8, Canada
Ioannis-Alexandros Drosatos
2nd Academic Department of Cardiology, Attikon University Hospital, University of Athens Medical School, 164 62 Athens, Greece
Sahil Gupta
Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, University of Toronto, Toronto, ON M5B 1W8, Canada
Hajera Amatullah
Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02210, USA
Shehla Izhar
Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, University of Toronto, Toronto, ON M5B 1W8, Canada
Claudia C. dos Santos
Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, University of Toronto, Toronto, ON M5B 1W8, Canada
Vasileos Salpeas
2nd Academic Department of Cardiology, Attikon University Hospital, University of Athens Medical School, 164 62 Athens, Greece
Angelos G. Rigopoulos
2nd Academic Department of Cardiology, Attikon University Hospital, University of Athens Medical School, 164 62 Athens, Greece
Ioannis K. Toumpoulis
2nd Academic Department of Cardiology, Attikon University Hospital, University of Athens Medical School, 164 62 Athens, Greece
Andreas S. Triantafyllis
2nd Academic Department of Cardiology, Attikon University Hospital, University of Athens Medical School, 164 62 Athens, Greece
Eleftharios Sakadakis
2nd Academic Department of Cardiology, Attikon University Hospital, University of Athens Medical School, 164 62 Athens, Greece
Nikolaos Kavantzas
1st Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, Greece
John C. Marshall
Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, University of Toronto, Toronto, ON M5B 1W8, Canada
Ioannis K. Rizos
2nd Academic Department of Cardiology, Attikon University Hospital, University of Athens Medical School, 164 62 Athens, Greece
Thomas G. Parker
Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, University of Toronto, Toronto, ON M5B 1W8, Canada
DJ-1 was originally identified as an oncogene product while mutations of the gene encoding DJ-1/PARK7 were later associated with a recessive form of Parkinson’s disease. Its ubiquitous expression and diversity of function suggest that DJ-1 is also involved in mechanisms outside the central nervous system. In the last decade, the contribution of DJ-1 to the protection from ischemia-reperfusion injury has been recognized and its involvement in the pathophysiology of cardiovascular disease is attracting increasing attention. This review describes the current and gaps in our knowledge of DJ-1, focusing on its role in regulating cardiovascular function. In parallel, we present original data showing an association between increased DJ-1 expression and antiapoptotic and anti-inflammatory markers following cardiac and vascular surgical procedures. Future studies should address DJ-1’s role as a plausible novel therapeutic target for cardiovascular disease.
