A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells

Rebecca A. Dagg; Gijs Zonderland; Emilia Puig Lombardi; Giacomo G. Rossetti; Florian J. Groelly; Sonia Barroso; Eliana M. C. Tacconi; Benjamin Wright; Helen Lockstone; Andrés Aguilera; Thanos D. Halazonetis; Madalena Tarsounas

doi:10.1038/s41467-021-25215-0

Nature Communications (Aug 2021)

A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells

Rebecca A. Dagg,
Gijs Zonderland,
Emilia Puig Lombardi,
Giacomo G. Rossetti,
Florian J. Groelly,
Sonia Barroso,
Eliana M. C. Tacconi,
Benjamin Wright,
Helen Lockstone,
Andrés Aguilera,
Thanos D. Halazonetis,
Madalena Tarsounas

Affiliations

Rebecca A. Dagg: Genome Stability and Tumourigenesis Group, MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford
Gijs Zonderland: Genome Stability and Tumourigenesis Group, MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford
Emilia Puig Lombardi: Genome Stability and Tumourigenesis Group, MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford
Giacomo G. Rossetti: Department of Molecular Biology, University of Geneva
Florian J. Groelly: Genome Stability and Tumourigenesis Group, MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford
Sonia Barroso: Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas-Universidad Pablo de Olavide
Eliana M. C. Tacconi: Genome Stability and Tumourigenesis Group, MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford
Benjamin Wright: Bioinformatics and Statistical Genetics Core, Wellcome Trust Centre for Human Genetics, University of Oxford
Helen Lockstone: Bioinformatics and Statistical Genetics Core, Wellcome Trust Centre for Human Genetics, University of Oxford
Andrés Aguilera: Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas-Universidad Pablo de Olavide
Thanos D. Halazonetis: Department of Molecular Biology, University of Geneva
Madalena Tarsounas: Genome Stability and Tumourigenesis Group, MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford

DOI: https://doi.org/10.1038/s41467-021-25215-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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Germline mutations in BRCA1 or BRCA2 tumour suppressor genes predispose to different cancers, as does oncogene activation. Here the authors reveal that aberrant transcription of specific genes triggered by activation of the oncogene β-catenin causes replication failure and cell death in the context of BRCA1/2 deficiency.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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