Dynamic Expression of m6A Regulators During Multiple Human Tissue Development and Cancers

Ya Zhang; Ya Zhang; Sicong Xu; Sicong Xu; Gang Xu; Gang Xu; Yueying Gao; Yueying Gao; Si Li; Si Li; Ke Zhang; Ke Zhang; Zhanyu Tian; Zhanyu Tian; Jing Guo; Jing Guo; Xia Li; Xia Li; Juan Xu; Juan Xu; Yongsheng Li; Yongsheng Li

doi:10.3389/fcell.2020.629030

Frontiers in Cell and Developmental Biology (Jan 2021)

Dynamic Expression of m6A Regulators During Multiple Human Tissue Development and Cancers

Ya Zhang,
Ya Zhang,
Sicong Xu,
Sicong Xu,
Gang Xu,
Gang Xu,
Yueying Gao,
Yueying Gao,
Si Li,
Si Li,
Ke Zhang,
Ke Zhang,
Zhanyu Tian,
Zhanyu Tian,
Jing Guo,
Jing Guo,
Xia Li,
Xia Li,
Juan Xu,
Juan Xu,
Yongsheng Li,
Yongsheng Li

Affiliations

Ya Zhang: Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China
Ya Zhang: College of Biomedical Information and Engineering, Hainan Medical University, Haikou, China
Sicong Xu: Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China
Sicong Xu: College of Biomedical Information and Engineering, Hainan Medical University, Haikou, China
Gang Xu: Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China
Gang Xu: College of Biomedical Information and Engineering, Hainan Medical University, Haikou, China
Yueying Gao: Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China
Yueying Gao: College of Biomedical Information and Engineering, Hainan Medical University, Haikou, China
Si Li: Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China
Si Li: College of Biomedical Information and Engineering, Hainan Medical University, Haikou, China
Ke Zhang: Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China
Ke Zhang: College of Biomedical Information and Engineering, Hainan Medical University, Haikou, China
Zhanyu Tian: Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China
Zhanyu Tian: College of Biomedical Information and Engineering, Hainan Medical University, Haikou, China
Jing Guo: Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China
Jing Guo: College of Biomedical Information and Engineering, Hainan Medical University, Haikou, China
Xia Li: Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China
Xia Li: College of Biomedical Information and Engineering, Hainan Medical University, Haikou, China
Juan Xu: Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China
Juan Xu: College of Biomedical Information and Engineering, Hainan Medical University, Haikou, China
Yongsheng Li: Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China
Yongsheng Li: College of Biomedical Information and Engineering, Hainan Medical University, Haikou, China

DOI: https://doi.org/10.3389/fcell.2020.629030
Journal volume & issue: Vol. 8

Abstract

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N6-methyladenosine (m6A) plays critical roles in human development and cancer progression. However, our knowledge regarding the dynamic expression of m6A regulators during human tissue development is still lacking. Here, we comprehensively analyzed the dynamic expression alterations of m6A regulators during seven tissue development and eight cancer types. We found that m6A regulators globally exhibited decreased expression during development. In addition, IGF2BP1/2/3 (insulinlike growth factor 2 MRNA-binding protein 1/2/3) exhibited reverse expression pattern in cancer progression, suggesting an oncofetal reprogramming in cancer. The expressions of IGF2BP1/2/3 were regulated by genome alterations, particularly copy number amplification in cancer. Clinical association analysis revealed that higher expressions of IGF2BP1/2/3 were associated with worse survival of cancer patients. Finally, we found that genes significantly correlated with IGF2BP1/2/3 were significantly enriched in cancer hallmark-related pathways. In summary, dynamic expression analysis will guide both mechanistic and therapeutic roles of m6A regulators during tissue development and cancer progression.

Published in Frontiers in Cell and Developmental Biology

ISSN: 2296-634X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/cell-and-developmental-biology

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