Cobra Venom Neutralization Effect by Hemidesmus indicus Root Extract

Abstract

Hemidesmus indicus (Apocynaceae) has been utilized traditionally in the Indian subcontinent for the treatment of snakebites and scorpion stings. It has also several beneficial bioactivities in human beings such as antidiabetic, anti-inflammatory and skin diseases. The purpose of this study was to assess the anti-venom capability of Hemidesmus indicus root extract against cobra venom (Naja nigricollis). Albino mice were utilized to test the plant’s efficacy using the venom of N. nigricollis. H. indicus root extract (600 mg/kg) neutralized cobra venom and generated 100 % survival, suggesting its antivenom potential. H. indicus showed a substantial antivenom effect (p0.05) against the venom of N. nigricollis, indicating that it might be a useful drug for treating snake venom. The present study provides scientific basis for use of root extract of H. indicus against N. nigricollis venom.

Keywords

• antivenom
• hemidesmus indicus
• naja nigricollis
• venom neutralization
• albino mice