Nature Communications (May 2016)
Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells
- Kerstin Göbel,
- Susann Pankratz,
- Chloi-Magdalini Asaridou,
- Alexander M. Herrmann,
- Stefan Bittner,
- Monika Merker,
- Tobias Ruck,
- Sarah Glumm,
- Friederike Langhauser,
- Peter Kraft,
- Thorsten F. Krug,
- Johanna Breuer,
- Martin Herold,
- Catharina C. Gross,
- Denise Beckmann,
- Adelheid Korb-Pap,
- Michael K. Schuhmann,
- Stefanie Kuerten,
- Ioannis Mitroulis,
- Clemens Ruppert,
- Marc W. Nolte,
- Con Panousis,
- Luisa Klotz,
- Beate Kehrel,
- Thomas Korn,
- Harald F. Langer,
- Thomas Pap,
- Bernhard Nieswandt,
- Heinz Wiendl,
- Triantafyllos Chavakis,
- Christoph Kleinschnitz,
- Sven G. Meuth
Affiliations
- Kerstin Göbel
- Department of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of Münster
- Susann Pankratz
- Department of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of Münster
- Chloi-Magdalini Asaridou
- Department of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of Münster
- Alexander M. Herrmann
- Department of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of Münster
- Stefan Bittner
- Department of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of Münster
- Monika Merker
- Department of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of Münster
- Tobias Ruck
- Department of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of Münster
- Sarah Glumm
- Department of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of Münster
- Friederike Langhauser
- Department of Neurology, University Hospital Würzburg
- Peter Kraft
- Department of Neurology, University Hospital Würzburg
- Thorsten F. Krug
- Department of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of Münster
- Johanna Breuer
- Department of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of Münster
- Martin Herold
- Department of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of Münster
- Catharina C. Gross
- Department of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of Münster
- Denise Beckmann
- Institute of Experimental Musculoskeletal Medicine, University Hospital Münster
- Adelheid Korb-Pap
- Institute of Experimental Musculoskeletal Medicine, University Hospital Münster
- Michael K. Schuhmann
- Department of Neurology, University Hospital Würzburg
- Stefanie Kuerten
- Department of Anatomy and Cell Biology, University of Würzburg
- Ioannis Mitroulis
- Department of Clinical Pathobiochemistry and Institute for Clinical Chemistry and Laboratory Medicine, University Clinic Carl Gustav Carus, Technische Universität of Dresden
- Clemens Ruppert
- Department of Internal Medicine, Universities of Giessen & Marburg Lung Center (UGMLC)/Member of the German Center for Lung Research (DZL), Justus-Liebig University
- Marc W. Nolte
- CSL Behring GmbH
- Con Panousis
- CSL Limited, Bio21 Institute
- Luisa Klotz
- Department of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of Münster
- Beate Kehrel
- Department of Anesthesiology, Intensive Care and Pain Medicine, Experimental and Clinical Hemostasis, University of Münster
- Thomas Korn
- Department of Neurology, Klinikum rechts der Isar, Technical University of Munich
- Harald F. Langer
- Department of Cardiology and Cardiovascular Medicine, Section for Cardioimmunology, University Clinic of Tübingen
- Thomas Pap
- Institute of Experimental Musculoskeletal Medicine, University Hospital Münster
- Bernhard Nieswandt
- Rudolf Virchow Center, Deutsche Forschungsgemeinschaft Research Center for Experimental Biomedicine, University of Würzburg
- Heinz Wiendl
- Department of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of Münster
- Triantafyllos Chavakis
- Department of Clinical Pathobiochemistry and Institute for Clinical Chemistry and Laboratory Medicine, University Clinic Carl Gustav Carus, Technische Universität of Dresden
- Christoph Kleinschnitz
- Department of Neurology, University Hospital Würzburg
- Sven G. Meuth
- Department of Neurology, Clinic of Neurology and Institute for Translational Neurology, University of Münster
- DOI
- https://doi.org/10.1038/ncomms11626
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 16
Abstract
Factor XII initiates the intrinsic blood coagulation cascade and the kinin system. Here the authors show that Factor XII is elevated in the blood of multiple sclerosis patients, activates dendritic cells via CD87 and cAMP, and its blockade inhibits immunopathology in a mouse model of the disease.
