Nature Communications (Mar 2021)

Single cell transcriptomics of primate sensory neurons identifies cell types associated with chronic pain

  • Jussi Kupari,
  • Dmitry Usoskin,
  • Marc Parisien,
  • Daohua Lou,
  • Yizhou Hu,
  • Michael Fatt,
  • Peter Lönnerberg,
  • Mats Spångberg,
  • Bengt Eriksson,
  • Nikolaos Barkas,
  • Peter V. Kharchenko,
  • Karin Loré,
  • Samar Khoury,
  • Luda Diatchenko,
  • Patrik Ernfors

DOI
https://doi.org/10.1038/s41467-021-21725-z
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

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The contribution of distinct types of dorsal root ganglion neurons to chronic pain is unclear. Here, the authors molecularly profile non-human primate sensory neurons and show that genome-wide associations converge on two neuronal types with different genetic susceptibilities for chronic pain.