Low peripheral blood derived neutrophil-to-lymphocyte ratio (dNLR) is associated with increased tumor T-cell infiltration and favorable outcomes to first-line pembrolizumab in non-small cell lung cancer

• James Lindsay,
• Mizuki Nishino,
• Biagio Ricciuti,
• Mark M. Awad,
• Joao V Alessi,
• Bijaya Sharma,
• Kathleen Pfaff,
• Kristen D Felt,
• Stephanie L Alden,
• Arrien A Bertram,
• Jessica J Lin,
• Mustafa Sakhi,
• Victor R Vaz,
• Madison M Turner,
• Scott J. Rodig,
• Justin F. Gainor

Affiliations

James Lindsay

Knowledge Systems Group, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

Mizuki Nishino

Department of Radiology, Brigham and Women’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA

Biagio Ricciuti

Lowe Center for Thoracic Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA

Mark M. Awad

Lowe Center for Thoracic Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA

Joao V Alessi

Lowe Center for Thoracic Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA

Bijaya Sharma

ImmunoProfile, Brigham & Women’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA

Kathleen Pfaff

ImmunoProfile, Brigham & Women’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA

Kristen D Felt

ImmunoProfile, Brigham & Women’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA

Stephanie L Alden

Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA

Arrien A Bertram

Lowe Center for Thoracic Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA

Jessica J Lin

Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, Massachusetts, USA

Mustafa Sakhi

Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, Massachusetts, USA

Victor R Vaz

Lowe Center for Thoracic Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA

Madison M Turner

ImmunoProfile, Brigham & Women’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA

Scott J. Rodig

Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA

Justin F. Gainor

Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, Massachusetts, USA