PLoS Biology (Apr 2024)

Genome-wide association studies have problems due to confounding: Are family-based designs the answer?

  • Alexander Strudwick Young

DOI
https://doi.org/10.1371/journal.pbio.3002568
Journal volume & issue
Vol. 22, no. 4
p. e3002568

Abstract

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Genome-wide association studies (GWASs) can be affected by confounding. Family-based GWAS uses random, within-family genetic variation to avoid this. A study in PLOS Biology details how different sources of confounding affect GWAS and whether family-based designs offer a solution.