Nature Communications (Aug 2018)
Circulating tumor DNA analysis depicts subclonal architecture and genomic evolution of small cell lung cancer
- Jingying Nong,
- Yuhua Gong,
- Yanfang Guan,
- Xin Yi,
- Yuting Yi,
- Lianpeng Chang,
- Ling Yang,
- Jialin Lv,
- Zhirong Guo,
- Hongyan Jia,
- Yuxing Chu,
- Tao Liu,
- Ming Chen,
- Lauren Byers,
- Emily Roarty,
- Vincent K. Lam,
- Vassiliki A. Papadimitrakopoulou,
- Ignacio Wistuba,
- John V. Heymach,
- Bonnie Glisson,
- Zhongxing Liao,
- J. Jack Lee,
- P. Andrew Futreal,
- Shucai Zhang,
- Xuefeng Xia,
- Jianjun Zhang,
- Jinghui Wang
Affiliations
- Jingying Nong
- Department of Medical Oncology, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute
- Yuhua Gong
- Geneplus-Beijing
- Yanfang Guan
- Geneplus-Beijing
- Xin Yi
- Geneplus-Beijing
- Yuting Yi
- Geneplus-Beijing
- Lianpeng Chang
- Geneplus-Beijing
- Ling Yang
- Geneplus-Beijing
- Jialin Lv
- Department of Medical Oncology, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute
- Zhirong Guo
- Beijing Key Laboratory for Drug Resistance Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute
- Hongyan Jia
- Beijing Key Laboratory for Drug Resistance Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute
- Yuxing Chu
- Geneplus-Beijing
- Tao Liu
- Geneplus-Beijing
- Ming Chen
- Department of Radiation Oncology, Zhejiang Cancer Hospital
- Lauren Byers
- Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center
- Emily Roarty
- Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center
- Vincent K. Lam
- Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center
- Vassiliki A. Papadimitrakopoulou
- Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center
- Ignacio Wistuba
- Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center
- John V. Heymach
- Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center
- Bonnie Glisson
- Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center
- Zhongxing Liao
- Department of Radiation Oncology, University of Texas MD Anderson Cancer Center
- J. Jack Lee
- Department of Biostatistics, University of Texas MD Anderson Cancer Center
- P. Andrew Futreal
- Department of Genomic Medicine, University of Texas MD Anderson Cancer Center
- Shucai Zhang
- Department of Medical Oncology, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute
- Xuefeng Xia
- Houston Methodist Research Institute
- Jianjun Zhang
- Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center
- Jinghui Wang
- Department of Medical Oncology, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute
- DOI
- https://doi.org/10.1038/s41467-018-05327-w
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 8
Abstract
Small cell lung cancer (SCLC) may evolve under treatment. But tumor tissues are often not available to study evolution of SCLC. Here, the authors utilize circulating tumor DNA to investigate the genomic evolution and subclonal architecture of SCLC during therapy.
