Nature Communications (Sep 2017)

Functional organization of cytoplasmic inclusion bodies in cells infected by respiratory syncytial virus

  • Vincent Rincheval,
  • Mickael Lelek,
  • Elyanne Gault,
  • Camille Bouillier,
  • Delphine Sitterlin,
  • Sabine Blouquit-Laye,
  • Marie Galloux,
  • Christophe Zimmer,
  • Jean-François Eleouet,
  • Marie-Anne Rameix-Welti

DOI
https://doi.org/10.1038/s41467-017-00655-9
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 11

Abstract

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Respiratory syncytial virus (RSV) induces formation of inclusion bodies (IBs) sheltering viral RNA synthesis. Here, Rincheval et al. identify highly dynamic IB-associated granules (IBAGs) that accumulate newly synthetized viral mRNA and the viral M2-1 protein but exclude viral genomic RNA and RNA polymerase complexes.