Nature Communications (Sep 2019)
Time elapsed between Zika and dengue virus infections affects antibody and T cell responses
- Erick X. Pérez-Guzmán,
- Petraleigh Pantoja,
- Crisanta Serrano-Collazo,
- Mariah A. Hassert,
- Alexandra Ortiz-Rosa,
- Idia V. Rodríguez,
- Luis Giavedoni,
- Vida Hodara,
- Laura Parodi,
- Lorna Cruz,
- Teresa Arana,
- Laura J. White,
- Melween I. Martínez,
- Daniela Weiskopf,
- James D. Brien,
- Aravinda de Silva,
- Amelia K. Pinto,
- Carlos A. Sariol
Affiliations
- Erick X. Pérez-Guzmán
- Department of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus
- Petraleigh Pantoja
- Department of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus
- Crisanta Serrano-Collazo
- Department of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus
- Mariah A. Hassert
- Department of Molecular Microbiology & Immunology, Saint Louis University School of Medicine
- Alexandra Ortiz-Rosa
- Department of Biology, University of Puerto Rico-Río Piedras Campus
- Idia V. Rodríguez
- Unit of Comparative Medicine, Caribbean Primate Research Center and Animal Resources Center, University of Puerto Rico-Medical Sciences Campus
- Luis Giavedoni
- Texas Biomedical Research Institute
- Vida Hodara
- Texas Biomedical Research Institute
- Laura Parodi
- Texas Biomedical Research Institute
- Lorna Cruz
- Department of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus
- Teresa Arana
- Department of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus
- Laura J. White
- Departments of Microbiology & Immunology, University of North Carolina-Chapel Hill
- Melween I. Martínez
- Department of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus
- Daniela Weiskopf
- Division of Vaccine Discovery, La Jolla Institute for Immunology
- James D. Brien
- Department of Molecular Microbiology & Immunology, Saint Louis University School of Medicine
- Aravinda de Silva
- Departments of Microbiology & Immunology, University of North Carolina-Chapel Hill
- Amelia K. Pinto
- Department of Molecular Microbiology & Immunology, Saint Louis University School of Medicine
- Carlos A. Sariol
- Department of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus
- DOI
- https://doi.org/10.1038/s41467-019-12295-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Here, the authors show that the time elapsed between Zika infection and subsequent dengue virus infection affects the magnitude and durability of the antibody and cell-mediated immune responses against dengue virus, but not viremia. This research in non-human primates has implications for co-endemic regions and vaccination.
