Nature Communications (Jul 2018)
PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity
- Jessica van Setten,
- Jennifer A. Brody,
- Yalda Jamshidi,
- Brenton R. Swenson,
- Anne M. Butler,
- Harry Campbell,
- Fabiola M. Del Greco,
- Daniel S. Evans,
- Quince Gibson,
- Daniel F. Gudbjartsson,
- Kathleen F. Kerr,
- Bouwe P. Krijthe,
- Leo-Pekka Lyytikäinen,
- Christian Müller,
- Martina Müller-Nurasyid,
- Ilja M. Nolte,
- Sandosh Padmanabhan,
- Marylyn D. Ritchie,
- Antonietta Robino,
- Albert V. Smith,
- Maristella Steri,
- Toshiko Tanaka,
- Alexander Teumer,
- Stella Trompet,
- Sheila Ulivi,
- Niek Verweij,
- Xiaoyan Yin,
- David O. Arnar,
- Folkert W. Asselbergs,
- Joel S. Bader,
- John Barnard,
- Josh Bis,
- Stefan Blankenberg,
- Eric Boerwinkle,
- Yuki Bradford,
- Brendan M. Buckley,
- Mina K. Chung,
- Dana Crawford,
- Marcel den Hoed,
- Josh C. Denny,
- Anna F. Dominiczak,
- Georg B. Ehret,
- Mark Eijgelsheim,
- Patrick T. Ellinor,
- Stephan B. Felix,
- Oscar H. Franco,
- Lude Franke,
- Tamara B. Harris,
- Hilma Holm,
- Gandin Ilaria,
- Annamaria Iorio,
- Mika Kähönen,
- Ivana Kolcic,
- Jan A. Kors,
- Edward G. Lakatta,
- Lenore J. Launer,
- Honghuang Lin,
- Henry J. Lin,
- Ruth J. F. Loos,
- Steven A. Lubitz,
- Peter W. Macfarlane,
- Jared W. Magnani,
- Irene Mateo Leach,
- Thomas Meitinger,
- Braxton D. Mitchell,
- Thomas Munzel,
- George J. Papanicolaou,
- Annette Peters,
- Arne Pfeufer,
- Peter P. Pramstaller,
- Olli T. Raitakari,
- Jerome I. Rotter,
- Igor Rudan,
- Nilesh J. Samani,
- David Schlessinger,
- Claudia T. Silva Aldana,
- Moritz F. Sinner,
- Jonathan D. Smith,
- Harold Snieder,
- Elsayed Z. Soliman,
- Timothy D. Spector,
- David J. Stott,
- Konstantin Strauch,
- Kirill V. Tarasov,
- Unnur Thorsteinsdottir,
- Andre G. Uitterlinden,
- David R. Van Wagoner,
- Uwe Völker,
- Henry Völzke,
- Melanie Waldenberger,
- Harm Jan Westra,
- Philipp S. Wild,
- Tanja Zeller,
- Alvaro Alonso,
- Christy L. Avery,
- Stefania Bandinelli,
- Emelia J. Benjamin,
- Francesco Cucca,
- Marcus Dörr,
- Luigi Ferrucci,
- Paolo Gasparini,
- Vilmundur Gudnason,
- Caroline Hayward,
- Susan R. Heckbert,
- Andrew A. Hicks,
- J. Wouter Jukema,
- Stefan Kääb,
- Terho Lehtimäki,
- Yongmei Liu,
- Patricia B. Munroe,
- Afshin Parsa,
- Ozren Polasek,
- Bruce M. Psaty,
- Dan M. Roden,
- Renate B. Schnabel,
- Gianfranco Sinagra,
- Kari Stefansson,
- Bruno H. Stricker,
- Pim van der Harst,
- Cornelia M. van Duijn,
- James F. Wilson,
- Sina A. Gharib,
- Paul I. W. de Bakker,
- Aaron Isaacs,
- Dan E. Arking,
- Nona Sotoodehnia
Affiliations
- Jessica van Setten
- Department of Cardiology, University Medical Center Utrecht, University of Utrecht
- Jennifer A. Brody
- Department of Medicine, Cardiovascular Health Research Unit, University of Washington
- Yalda Jamshidi
- Cardiogenetics Lab, Molecular and Clinical Sciences Research Institute, St George’s University of London
- Brenton R. Swenson
- Department of Medicine, Cardiovascular Health Research Unit, University of Washington
- Anne M. Butler
- Division of Infectious Diseases, Washington University School of Medicine
- Harry Campbell
- Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
- Fabiola M. Del Greco
- Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck
- Daniel S. Evans
- California Pacific Medical Center Research Institute
- Quince Gibson
- Department of Surgery, University of Alabama Birmingham Hospital
- Daniel F. Gudbjartsson
- deCODE genetics/Amgen, Inc.
- Kathleen F. Kerr
- Department of Biostatistics, School of Public Health, University of Washington
- Bouwe P. Krijthe
- Department of Epidemiology, Erasmus Medical Center
- Leo-Pekka Lyytikäinen
- Department of Clinical Chemistry, Fimlab Laboratories
- Christian Müller
- Department of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf
- Martina Müller-Nurasyid
- Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health
- Ilja M. Nolte
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Sandosh Padmanabhan
- Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow
- Marylyn D. Ritchie
- Department of Genetics, University of Pennsylvania
- Antonietta Robino
- Institute for Maternal and Child Health—IRCCS “Burlo Garofolo”
- Albert V. Smith
- Icelandic Heart Association
- Maristella Steri
- Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR)
- Toshiko Tanaka
- Translational Gerontology Branch, NIA
- Alexander Teumer
- Institute for Community Medicine, University Medicine Greifswald
- Stella Trompet
- Department of Cardiology, Leiden University Medical Center
- Sheila Ulivi
- Institute for Maternal and Child Health—IRCCS “Burlo Garofolo”
- Niek Verweij
- Department of Cardiology, University Medical Center Groningen, University of Groningen
- Xiaoyan Yin
- Department of Medicine, Boston University School of Medicine
- David O. Arnar
- deCODE genetics/Amgen, Inc.
- Folkert W. Asselbergs
- Department of Cardiology, University Medical Center Utrecht, University of Utrecht
- Joel S. Bader
- Department of Biomedical Engineering, Johns Hopkins University
- John Barnard
- Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic
- Josh Bis
- Department of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf
- Stefan Blankenberg
- DZHK (German Center for Cardiovascular Research) Partner Site
- Eric Boerwinkle
- Human Genetics Center, University of Texas Health Science Center at Houston
- Yuki Bradford
- Department of Genetics, University of Pennsylvania
- Brendan M. Buckley
- Department of Pharmacology and Therapeutics, University College Cork
- Mina K. Chung
- Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic
- Dana Crawford
- Institute for Computational Biology, Department of Population and Quantitative Health Sciences, Case Western Reserve University
- Marcel den Hoed
- Department of Immunology, Genetics and Pathology, Uppsala University
- Josh C. Denny
- Biomedical Informatics and Medicine, Vanderbilt University
- Anna F. Dominiczak
- Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow
- Georg B. Ehret
- Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
- Mark Eijgelsheim
- Department of Epidemiology, Erasmus Medical Center
- Patrick T. Ellinor
- Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard
- Stephan B. Felix
- DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald
- Oscar H. Franco
- Department of Epidemiology, Erasmus Medical Center
- Lude Franke
- Department of Genetics, University of Groningen, University Medical Center Groningen
- Tamara B. Harris
- Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health
- Hilma Holm
- deCODE genetics/Amgen, Inc.
- Gandin Ilaria
- Department of Medical Sciences, University of Trieste
- Annamaria Iorio
- Cardiovascular Department, “Ospedali Riuniti and University of Trieste”
- Mika Kähönen
- Department of Clinical Physiology, Tampere University Hospital
- Ivana Kolcic
- Faculty of Medicine, University of Split
- Jan A. Kors
- Department of Medical Informatics, Erasmus University Medical Center
- Edward G. Lakatta
- Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health
- Lenore J. Launer
- Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health
- Honghuang Lin
- Department of Medicine, Boston University School of Medicine
- Henry J. Lin
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Ruth J. F. Loos
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Steven A. Lubitz
- Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard
- Peter W. Macfarlane
- Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow
- Jared W. Magnani
- Department of Medicine, Division of Cardiology, University of Pittsburgh Medical Center Heart and Vascular Institute, University of Pittsburgh
- Irene Mateo Leach
- Department of Cardiology, University Medical Center Groningen, University of Groningen
- Thomas Meitinger
- DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance
- Braxton D. Mitchell
- Department of Medicine, University of Maryland School of Medicine, Geriatrics Research and Education Clinical Center, Baltimore VA Medical Center
- Thomas Munzel
- Center for Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz
- George J. Papanicolaou
- Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, NIH
- Annette Peters
- DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance
- Arne Pfeufer
- MVZ für Molekulardiagnostik
- Peter P. Pramstaller
- Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck
- Olli T. Raitakari
- Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital
- Jerome I. Rotter
- Departments of Medicine and Pediatrics, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Igor Rudan
- Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
- Nilesh J. Samani
- Department of Cardiovascular Sciences, University of Leicester
- David Schlessinger
- Laboratory of Genetics and Genomics, National Institute on Aging, National Institute of Health
- Claudia T. Silva Aldana
- Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center
- Moritz F. Sinner
- Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich
- Jonathan D. Smith
- Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic
- Harold Snieder
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Elsayed Z. Soliman
- Epidemiological Cardiology Research Center, Wake Forest School of Medicine
- Timothy D. Spector
- Department of Twin Research and Genetic Epidemiology, St Thomas Hospital, King’s College London
- David J. Stott
- Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow
- Konstantin Strauch
- Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health
- Kirill V. Tarasov
- Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health
- Unnur Thorsteinsdottir
- deCODE genetics/Amgen, Inc.
- Andre G. Uitterlinden
- Department of Internal Medicine, Erasmus Medical Center
- David R. Van Wagoner
- Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic
- Uwe Völker
- DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald
- Henry Völzke
- Institute for Community Medicine, University Medicine Greifswald
- Melanie Waldenberger
- DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance
- Harm Jan Westra
- Department of Genetics, University of Groningen, University Medical Center Groningen
- Philipp S. Wild
- DZHK (German Center for Cardiovascular Research), Partner Site Rhine-Main
- Tanja Zeller
- Department of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf
- Alvaro Alonso
- Department of Epidemiology, Rollins School of Public Health, Emory University
- Christy L. Avery
- Department of Epidemiology and Carolina Population Center, University of North Carolina at Chapel Hill
- Stefania Bandinelli
- Geriatric Unit, Azienda Sanitaria Firenze (ASF)
- Emelia J. Benjamin
- Durrer Center for Cardiogenetic Research, Netherlands Heart Institute
- Francesco Cucca
- Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR)
- Marcus Dörr
- DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald
- Luigi Ferrucci
- Translational Gerontology Branch, NIA
- Paolo Gasparini
- Institute for Maternal and Child Health—IRCCS “Burlo Garofolo”
- Vilmundur Gudnason
- Icelandic Heart Association
- Caroline Hayward
- Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Susan R. Heckbert
- Cardiovascular Health Research Unit and the Department of Epidemiology, University of Washington
- Andrew A. Hicks
- Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck
- J. Wouter Jukema
- Department of Cardiology, Leiden University Medical Center
- Stefan Kääb
- Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich
- Terho Lehtimäki
- Department of Clinical Chemistry, Fimlab Laboratories
- Yongmei Liu
- Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University
- Patricia B. Munroe
- Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London
- Afshin Parsa
- Department of Medicine, University of Maryland School of Medicine and Baltimore VA Medical Center
- Ozren Polasek
- Faculty of Medicine, University of Split
- Bruce M. Psaty
- Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington
- Dan M. Roden
- Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University
- Renate B. Schnabel
- Department of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf
- Gianfranco Sinagra
- Cardiovascular Department, “Ospedali Riuniti and University of Trieste”
- Kari Stefansson
- deCODE genetics/Amgen, Inc.
- Bruno H. Stricker
- Department of Epidemiology, Erasmus Medical Center
- Pim van der Harst
- Department of Cardiology, University Medical Center Groningen, University of Groningen
- Cornelia M. van Duijn
- Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center
- James F. Wilson
- Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
- Sina A. Gharib
- Cardiovascular Health Research Unit, Division of Pulmonary Critical Care and Sleep Medicine, Computational Medicine Core at Center for Lung Biology, Department of Medicine, University of Washington
- Paul I. W. de Bakker
- Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht
- Aaron Isaacs
- CARIM School for Cardiovascular Diseases
- Dan E. Arking
- McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
- Nona Sotoodehnia
- Departments of Medicine and Epidemiology, Cardiovascular Health Research Unit, Division of Cardiology, University of Washington
- DOI
- https://doi.org/10.1038/s41467-018-04766-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Abnormal PR interval duration is associated with risk for atrial fibrillation and heart block. Here, van Setten et al. identify 44 PR interval loci in a genome-wide association study of over 92,000 individuals and find genetic overlap with QRS duration, heart rate and atrial fibrillation.
