SARS-CoV-2 infection in a patient on chronic hydroxychloroquine therapy: Implications for prophylaxis
Khalid M. Dousa,
Sharad S. Malavade,
Jennifer Furin,
Barbara Gripshover,
Marjorie Hatszegi,
Leila Hojat,
Elie Saade,
Robert A. Salata
Affiliations
Khalid M. Dousa
Division of Infectious Diseases and HIV Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH, USA; Corresponding author at: Department of Infectious Diseases and HIV Medicine, Case Western Reserve University, University Hospitals Cleveland Medical Center, 11100 Euclid Avenue, Foley Building, Room 416, Cleveland, OH, USA.
Sharad S. Malavade
Division of Infectious Diseases and HIV Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH, USA
Jennifer Furin
Division of Infectious Diseases and HIV Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH, USA
Barbara Gripshover
Division of Infectious Diseases and HIV Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH, USA
Marjorie Hatszegi
Division of Infectious Diseases and HIV Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH, USA; Roe Green Center for Travel Medicine and Global Health, University Hospitals Cleveland Medical Center, Cleveland, OH, USA
Leila Hojat
Division of Infectious Diseases and HIV Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH, USA
Elie Saade
Division of Infectious Diseases and HIV Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH, USA
Robert A. Salata
Division of Infectious Diseases and HIV Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH, USA; Roe Green Center for Travel Medicine and Global Health, University Hospitals Cleveland Medical Center, Cleveland, OH, USA
People exposed to COVID-19 have a risk of developing disease, and health care workers are at risk at a time when they are badly needed during a health care crisis. Hydroxychloroquine and chloroquine have been used as treatment and are being considered as prophylaxis. Our patient developed COVID-19 while on hydroxychloroquine and although more work is needed, this calls into question the role of these medications as preventive therapy.
