Frontiers in Pediatrics (Apr 2022)
The Relationship Between Cord Blood Cytokine Levels and Perinatal Characteristics and Bronchopulmonary Dysplasia: A Case–Control Study
- Mengmeng Wang,
- Mengmeng Wang,
- Mengmeng Wang,
- Chenghan Luo,
- Zanyang Shi,
- Zanyang Shi,
- Zanyang Shi,
- Xinru Cheng,
- Xinru Cheng,
- Xinru Cheng,
- Mengyuan Lei,
- Wenjun Cao,
- Wenjun Cao,
- Wenjun Cao,
- Jingdi Zhang,
- Jingdi Zhang,
- Jingdi Zhang,
- Jian Ge,
- Jian Ge,
- Jian Ge,
- Min Song,
- Min Song,
- Min Song,
- Wenqian Ding,
- Wenqian Ding,
- Wenqian Ding,
- Yixia Zhang,
- Yixia Zhang,
- Yixia Zhang,
- Min Zhao,
- Qian Zhang,
- Qian Zhang,
- Qian Zhang
Affiliations
- Mengmeng Wang
- Neonatal Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Mengmeng Wang
- Clinical Treatment and Follow-Up Center for High-Risk Newborns of Henan Province, Zhengzhou, China
- Mengmeng Wang
- Key Laboratory for Prevention and Control of Developmental Disorders, Zhengzhou, China
- Chenghan Luo
- Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Zanyang Shi
- Neonatal Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Zanyang Shi
- Clinical Treatment and Follow-Up Center for High-Risk Newborns of Henan Province, Zhengzhou, China
- Zanyang Shi
- Key Laboratory for Prevention and Control of Developmental Disorders, Zhengzhou, China
- Xinru Cheng
- Neonatal Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Xinru Cheng
- Clinical Treatment and Follow-Up Center for High-Risk Newborns of Henan Province, Zhengzhou, China
- Xinru Cheng
- Key Laboratory for Prevention and Control of Developmental Disorders, Zhengzhou, China
- Mengyuan Lei
- Health Care Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Wenjun Cao
- Neonatal Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Wenjun Cao
- Clinical Treatment and Follow-Up Center for High-Risk Newborns of Henan Province, Zhengzhou, China
- Wenjun Cao
- Key Laboratory for Prevention and Control of Developmental Disorders, Zhengzhou, China
- Jingdi Zhang
- Neonatal Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Jingdi Zhang
- Clinical Treatment and Follow-Up Center for High-Risk Newborns of Henan Province, Zhengzhou, China
- Jingdi Zhang
- Key Laboratory for Prevention and Control of Developmental Disorders, Zhengzhou, China
- Jian Ge
- Neonatal Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Jian Ge
- Clinical Treatment and Follow-Up Center for High-Risk Newborns of Henan Province, Zhengzhou, China
- Jian Ge
- Key Laboratory for Prevention and Control of Developmental Disorders, Zhengzhou, China
- Min Song
- Neonatal Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Min Song
- Clinical Treatment and Follow-Up Center for High-Risk Newborns of Henan Province, Zhengzhou, China
- Min Song
- Key Laboratory for Prevention and Control of Developmental Disorders, Zhengzhou, China
- Wenqian Ding
- Neonatal Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Wenqian Ding
- Clinical Treatment and Follow-Up Center for High-Risk Newborns of Henan Province, Zhengzhou, China
- Wenqian Ding
- Key Laboratory for Prevention and Control of Developmental Disorders, Zhengzhou, China
- Yixia Zhang
- Neonatal Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Yixia Zhang
- Clinical Treatment and Follow-Up Center for High-Risk Newborns of Henan Province, Zhengzhou, China
- Yixia Zhang
- Key Laboratory for Prevention and Control of Developmental Disorders, Zhengzhou, China
- Min Zhao
- Medical Record Management Section, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Qian Zhang
- Neonatal Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Qian Zhang
- Clinical Treatment and Follow-Up Center for High-Risk Newborns of Henan Province, Zhengzhou, China
- Qian Zhang
- Key Laboratory for Prevention and Control of Developmental Disorders, Zhengzhou, China
- DOI
- https://doi.org/10.3389/fped.2022.807932
- Journal volume & issue
-
Vol. 10
Abstract
ObjectiveTo establish the association between serial levels of inflammatory cytokines in cord blood and perinatal characteristics and bronchopulmonary dysplasia (BPD) in preterm infants.Methods147 premature infants with gestational age ≤32 weeks who were born and hospitalized in the First Affiliated Hospital of Zhengzhou University between July 2019 and August 2021 were enrolled in this retrospective case–control study. Multiple microsphere flow immunofluorescence was used to detect seven cytokines in cord blood collected within 24 h of birth. Demographics, delivery characteristics, maternal factors, neonatal characteristics, and clinical outcomes were collected for the two groups. An unconditional logistic regression model was used in this study to assess the clinical variables.ResultsIL-6 cord blood levels at birth were significantly higher in the BPD group than in the non-BPD group, but the odds ratio (OR) was very small (OR = 1). No differences in other cytokine concentrations were observed between the two groups. Multivariable logistic regression analysis demonstrated that increased maternal white blood cell (WBC) count on admission and lower birth weight increased the risk of BPD progression.ConclusionsIncreased IL-6 cord blood levels at birth in preterm infants may have trivial significance for predicting BPD. Furthermore, higher maternal WBC count on admission and lower birth weight increased the risk of BPD.
Keywords