Nature Communications (Jul 2022)
Transcription factor network analysis identifies REST/NRSF as an intrinsic regulator of CNS regeneration in mice
- Yuyan Cheng,
- Yuqin Yin,
- Alice Zhang,
- Alexander M. Bernstein,
- Riki Kawaguchi,
- Kun Gao,
- Kyra Potter,
- Hui-Ya Gilbert,
- Yan Ao,
- Jing Ou,
- Catherine J. Fricano-Kugler,
- Jeffrey L. Goldberg,
- Zhigang He,
- Clifford J. Woolf,
- Michael V. Sofroniew,
- Larry I. Benowitz,
- Daniel H. Geschwind
Affiliations
- Yuyan Cheng
- Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles
- Yuqin Yin
- Department of Neurosurgery, Boston Children’s Hospital
- Alice Zhang
- Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles
- Alexander M. Bernstein
- Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles
- Riki Kawaguchi
- Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles
- Kun Gao
- Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles
- Kyra Potter
- Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles
- Hui-Ya Gilbert
- Department of Neurosurgery, Boston Children’s Hospital
- Yan Ao
- Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles
- Jing Ou
- Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles
- Catherine J. Fricano-Kugler
- Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles
- Jeffrey L. Goldberg
- Byers Eye Institute and Wu Tsai Neuroscience Institute, Stanford University
- Zhigang He
- F.M. Kirby Neurobiology Center, Boston Children’s Hospital
- Clifford J. Woolf
- F.M. Kirby Neurobiology Center, Boston Children’s Hospital
- Michael V. Sofroniew
- Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles
- Larry I. Benowitz
- Department of Neurosurgery, Boston Children’s Hospital
- Daniel H. Geschwind
- Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles
- DOI
- https://doi.org/10.1038/s41467-022-31960-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 22
Abstract
Here the authors couple an integrative genomic analysis with substantial in vitro and in vivo experimental validation, identifying REST as a novel suppressor of a pro-regenerative gene program and CNS axon regeneration in mice.
