Journal of Clinical Medicine (May 2021)

Platelet Transfusion—Insights from Current Practice to Future Development

  • Annina Capraru,
  • Katarzyna Aleksandra Jalowiec,
  • Cesare Medri,
  • Michael Daskalakis,
  • Sacha Sergio Zeerleder,
  • Behrouz Mansouri Taleghani

DOI
https://doi.org/10.3390/jcm10091990
Journal volume & issue
Vol. 10, no. 9
p. 1990

Abstract

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Since the late sixties, therapeutic or prophylactic platelet transfusion has been used to relieve hemorrhagic complications of patients with, e.g., thrombocytopenia, platelet dysfunction, and injuries, and is an essential part of the supportive care in high dose chemotherapy. Current and upcoming advances will significantly affect present standards. We focus on specific issues, including the comparison of buffy-coat (BPC) and apheresis platelet concentrates (APC); plasma additive solutions (PAS); further measures for improvement of platelet storage quality; pathogen inactivation; and cold storage of platelets. The objective of this article is to give insights from current practice to future development on platelet transfusion, focusing on these selected issues, which have a potentially major impact on forthcoming guidelines.

Keywords