Nature Communications (Jun 2018)
Gene flow contributes to diversification of the major fungal pathogen Candida albicans
- Jeanne Ropars,
- Corinne Maufrais,
- Dorothée Diogo,
- Marina Marcet-Houben,
- Aurélie Perin,
- Natacha Sertour,
- Kevin Mosca,
- Emmanuelle Permal,
- Guillaume Laval,
- Christiane Bouchier,
- Laurence Ma,
- Katja Schwartz,
- Kerstin Voelz,
- Robin C. May,
- Julie Poulain,
- Christophe Battail,
- Patrick Wincker,
- Andrew M. Borman,
- Anuradha Chowdhary,
- Shangrong Fan,
- Soo Hyun Kim,
- Patrice Le Pape,
- Orazio Romeo,
- Jong Hee Shin,
- Toni Gabaldon,
- Gavin Sherlock,
- Marie-Elisabeth Bougnoux,
- Christophe d’Enfert
Affiliations
- Jeanne Ropars
- Department of Mycology, Fungal Biology and Pathogenicity Unit, Institut Pasteur, INRA
- Corinne Maufrais
- Department of Mycology, Fungal Biology and Pathogenicity Unit, Institut Pasteur, INRA
- Dorothée Diogo
- Department of Mycology, Fungal Biology and Pathogenicity Unit, Institut Pasteur, INRA
- Marina Marcet-Houben
- Department of Mycology, Fungal Biology and Pathogenicity Unit, Institut Pasteur, INRA
- Aurélie Perin
- Department of Mycology, Fungal Biology and Pathogenicity Unit, Institut Pasteur, INRA
- Natacha Sertour
- Department of Mycology, Fungal Biology and Pathogenicity Unit, Institut Pasteur, INRA
- Kevin Mosca
- Department of Mycology, Fungal Biology and Pathogenicity Unit, Institut Pasteur, INRA
- Emmanuelle Permal
- Department of Mycology, Fungal Biology and Pathogenicity Unit, Institut Pasteur, INRA
- Guillaume Laval
- Center for Bioinformatics, BioStatistics and Integrative Biology (C3BI), USR 3756 IP CNRS, Institut Pasteur
- Christiane Bouchier
- Biomics Pole, CITECH, Institut Pasteur
- Laurence Ma
- Biomics Pole, CITECH, Institut Pasteur
- Katja Schwartz
- Department of Genetics, Stanford University Medical School
- Kerstin Voelz
- School of Biosciences and Institute of Microbiology and Infection, University of Birmingham
- Robin C. May
- School of Biosciences and Institute of Microbiology and Infection, University of Birmingham
- Julie Poulain
- CEA, Genoscope, Institut de biologie François Jacob
- Christophe Battail
- CEA, Genoscope, Institut de biologie François Jacob
- Patrick Wincker
- CEA, Genoscope, Institut de biologie François Jacob
- Andrew M. Borman
- UK National Mycology Reference Laboratory, Public Health England
- Anuradha Chowdhary
- Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi
- Shangrong Fan
- Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital
- Soo Hyun Kim
- Department of Laboratory Medicine, Chonnam National University Medical School
- Patrice Le Pape
- EA1155 – IICiMed, Institut de Recherche en Santé 2, Université de Nantes
- Orazio Romeo
- Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina
- Jong Hee Shin
- Department of Laboratory Medicine, Chonnam National University Medical School
- Toni Gabaldon
- Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology
- Gavin Sherlock
- Department of Genetics, Stanford University Medical School
- Marie-Elisabeth Bougnoux
- Department of Mycology, Fungal Biology and Pathogenicity Unit, Institut Pasteur, INRA
- Christophe d’Enfert
- Department of Mycology, Fungal Biology and Pathogenicity Unit, Institut Pasteur, INRA
- DOI
- https://doi.org/10.1038/s41467-018-04787-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 10
Abstract
The fungal pathogen Candida albicans can undergo a parasexual process that may contribute to genetic diversity, but its actual relevance is unclear. Here, Ropars et al. analyse the genomic sequences of 182 C. albicans isolates collected worldwide and find evidence of gene flow and thus parasexuality in nature.
