Structures of human dual oxidase 1 complex in low-calcium and high-calcium states

Jing-Xiang Wu; Rui Liu; Kangcheng Song; Lei Chen

doi:10.1038/s41467-020-20466-9

Nature Communications (Jan 2021)

Structures of human dual oxidase 1 complex in low-calcium and high-calcium states

Jing-Xiang Wu,
Rui Liu,
Kangcheng Song,
Lei Chen

Affiliations

Jing-Xiang Wu: State Key Laboratory of Membrane Biology, College of Future Technology, Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University
Rui Liu: State Key Laboratory of Membrane Biology, College of Future Technology, Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University
Kangcheng Song: State Key Laboratory of Membrane Biology, College of Future Technology, Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University
Lei Chen: State Key Laboratory of Membrane Biology, College of Future Technology, Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University

DOI: https://doi.org/10.1038/s41467-020-20466-9
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

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Dual oxidases (DUOXs), assembled from the catalytic DUOX and the auxiliary DUOXA subunits, produce hydrogen peroxide by transferring electrons from intracellular NADPH to extracellular oxygen in a calcium-activated manner. Here authors report the cryo-EM structures of human DUOX1-DUOXA1 complex in both high-calcium and low-calcium states.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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