Department of Control Theory and System Dynamics, Neurotechnology Department, National Research Lobachevsky State University of Nizhny Novgorod, 603022 Nizhny Novgorod, Russia
Anna Beltyukova
Department of Control Theory and System Dynamics, Neurotechnology Department, National Research Lobachevsky State University of Nizhny Novgorod, 603022 Nizhny Novgorod, Russia
Anastasia Fedulina
Department of Control Theory and System Dynamics, Neurotechnology Department, National Research Lobachevsky State University of Nizhny Novgorod, 603022 Nizhny Novgorod, Russia
Maria Matveeva
Department of Control Theory and System Dynamics, Neurotechnology Department, National Research Lobachevsky State University of Nizhny Novgorod, 603022 Nizhny Novgorod, Russia
Albina V. Lebedeva
Department of Control Theory and System Dynamics, Neurotechnology Department, National Research Lobachevsky State University of Nizhny Novgorod, 603022 Nizhny Novgorod, Russia
Alexander N. Pisarchik
Center for Biomedical Technology, Universidad Politécnica de Madrid, Pozuelo de Alarcón, 28223 Madrid, Spain
We present a novel closed-loop system designed to integrate biological and artificial neurons of the oscillatory type into a unified circuit. The system comprises an electronic circuit based on the FitzHugh-Nagumo model, which provides stimulation to living neurons in acute hippocampal mouse brain slices. The local field potentials generated by the living neurons trigger a transition in the FitzHugh–Nagumo circuit from an excitable state to an oscillatory mode, and in turn, the spikes produced by the electronic circuit synchronize with the living-neuron spikes. The key advantage of this hybrid electrobiological autogenerator lies in its capability to control biological neuron signals, which holds significant promise for diverse neuromorphic applications.
