Axotomy-induced HIF-serotonin signalling axis promotes axon regeneration in C. elegans

Abstract

The molecular mechanism of axon regeneration after injury is poorly understood. Here the authors show that in C. elegans, the HIF-1 transcription factor induces ectopic synthesis of serotonin in severed ‘non-serotonergic’ neurons and that serotonin activates downstream signaling pathways leading to axon regeneration.