Synthesis of aliphatic nitriles from cyclobutanone oxime mediated by sulfuryl fluoride (SO2F2)

Abstract

A SO2F2-mediated ring-opening cross-coupling of cyclobutanone oxime derivatives with alkenes was developed for the construction of a range of δ-olefin-containing aliphatic nitriles with (E)-configuration selectivity. This new method features wide substrate scope, mild conditions, and direct N–O activation.

Keywords

• direct n–o activation
• e-selectivity
• nitrile synthesis
• ring-opening cross-coupling
• sulfuryl fluoride
• so2f2