Mechanisms of oxidative stress in the pathogenesis of chronic bacterial prostatitis (literature review)

Abstract

The review article, based on the results of modern clinical and experimental studies, discusses general issues of the pathophysiology of oxidative stress as a universal pathogenetic factor of human diseases and particular pathophysiological aspects of oxidative stress on the example of chronic bacterial prostatitis. Separately, the most studied mechanisms of oxidative stress in the pathogenesis of the infectious and inflammatory process associated with chronic bacterial prostatitis are highlighted, which contribute to the occurrence and persistence of oxidative disorders in the prostate gland and disrupt the full restoration of its anatomical and functional state after inflammation with a potentially negative effect on the results of standard chronic bacterial prostatitis pharmacotherapy.

Keywords

• chronic bacterial prostatitis
• oxidative stress
• reactive oxygen species
• lipid peroxidation
• membranopathy
• antioxidant defense system
• antioxidants