Nature Communications (Jun 2018)
Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity
- Emelie Berglund,
- Jonas Maaskola,
- Niklas Schultz,
- Stefanie Friedrich,
- Maja Marklund,
- Joseph Bergenstråhle,
- Firas Tarish,
- Anna Tanoglidi,
- Sanja Vickovic,
- Ludvig Larsson,
- Fredrik Salmén,
- Christoph Ogris,
- Karolina Wallenborg,
- Jens Lagergren,
- Patrik Ståhl,
- Erik Sonnhammer,
- Thomas Helleday,
- Joakim Lundeberg
Affiliations
- Emelie Berglund
- Department of Gene Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology (KTH), Science for Life Laboratory
- Jonas Maaskola
- Department of Gene Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology (KTH), Science for Life Laboratory
- Niklas Schultz
- Department of Oncology-Pathology, Karolinska Institutet (KI), Science for Life Laboratory
- Stefanie Friedrich
- Department of Biochemistry and Biophysics, Stockholm University, Science for Life Laboratory
- Maja Marklund
- Department of Gene Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology (KTH), Science for Life Laboratory
- Joseph Bergenstråhle
- Department of Gene Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology (KTH), Science for Life Laboratory
- Firas Tarish
- Department of Oncology-Pathology, Karolinska Institutet (KI), Science for Life Laboratory
- Anna Tanoglidi
- Department of Clinical Pathology, University Uppsala Hospital
- Sanja Vickovic
- Department of Gene Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology (KTH), Science for Life Laboratory
- Ludvig Larsson
- Department of Gene Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology (KTH), Science for Life Laboratory
- Fredrik Salmén
- Department of Gene Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology (KTH), Science for Life Laboratory
- Christoph Ogris
- Department of Biochemistry and Biophysics, Stockholm University, Science for Life Laboratory
- Karolina Wallenborg
- Department of Oncology-Pathology, Karolinska Institutet (KI), Science for Life Laboratory
- Jens Lagergren
- Department of Computational Biology, School of Computer Science and Communication, Royal Institute of Technology (KTH), Science for Life Laboratory
- Patrik Ståhl
- Department of Gene Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology (KTH), Science for Life Laboratory
- Erik Sonnhammer
- Department of Biochemistry and Biophysics, Stockholm University, Science for Life Laboratory
- Thomas Helleday
- Department of Oncology-Pathology, Karolinska Institutet (KI), Science for Life Laboratory
- Joakim Lundeberg
- Department of Gene Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology (KTH), Science for Life Laboratory
- DOI
- https://doi.org/10.1038/s41467-018-04724-5
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Heterogeneity within tumors presents a challenge to cancer treatment. Here, the authors investigate transcriptional heterogeneity in prostate cancer, examining expression profiles of different tissue components and highlighting expression gradients in the tumor microenvironment.
