mSphere of Influence: Rapid evolution of pathogenesis and drug resistance in human pathogenic fungi

Abstract

ABSTRACT Pengjie Hu works in the field of fungal pathogenesis, drug resistance, and evolution. In this mSphere of Influence article, he reflects on how three works, “Transposon mobilization in the human fungal pathogen Cryptococcus is mutagenic during infection and promotes drug resistance in vitro” and “Genome-wide analysis of heat stress-stimulated transposon mobility in the human fungal pathogen Cryptococcus deneoformans” by Gusa et al. and “Rapid evolution of an adaptive multicellular morphology of Candida auris during systemic infection” by Bing et al. have impacted his work on the evolution of virulence, resistance, and adaptation in human fungal pathogens.

Keywords

• human fungal pathogen
• evolution
• genetic mutation
• pathogenesis
• drug resistance
• adaptation