Nature Communications (Oct 2019)
Evolution and regulation of nitrogen flux through compartmentalized metabolic networks in a marine diatom
- Sarah R. Smith,
- Chris L. Dupont,
- James K. McCarthy,
- Jared T. Broddrick,
- Miroslav Oborník,
- Aleš Horák,
- Zoltán Füssy,
- Jaromír Cihlář,
- Sabrina Kleessen,
- Hong Zheng,
- John P. McCrow,
- Kim K. Hixson,
- Wagner L. Araújo,
- Adriano Nunes-Nesi,
- Alisdair Fernie,
- Zoran Nikoloski,
- Bernhard O. Palsson,
- Andrew E. Allen
Affiliations
- Sarah R. Smith
- Microbial and Environmental Genomics, J. Craig Venter Institute
- Chris L. Dupont
- Microbial and Environmental Genomics, J. Craig Venter Institute
- James K. McCarthy
- Microbial and Environmental Genomics, J. Craig Venter Institute
- Jared T. Broddrick
- Division of Biological Sciences, University of California, San Diego
- Miroslav Oborník
- Institute of Parasitology, Biology Centre Czech Academy of Sciences
- Aleš Horák
- Institute of Parasitology, Biology Centre Czech Academy of Sciences
- Zoltán Füssy
- Institute of Parasitology, Biology Centre Czech Academy of Sciences
- Jaromír Cihlář
- Institute of Parasitology, Biology Centre Czech Academy of Sciences
- Sabrina Kleessen
- Targenomix, GmbH
- Hong Zheng
- Microbial and Environmental Genomics, J. Craig Venter Institute
- John P. McCrow
- Microbial and Environmental Genomics, J. Craig Venter Institute
- Kim K. Hixson
- Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory
- Wagner L. Araújo
- Departamento de Biologia Vegetal, Universidade Federal de Viçosa
- Adriano Nunes-Nesi
- Departamento de Biologia Vegetal, Universidade Federal de Viçosa
- Alisdair Fernie
- Max Planck Institut of Molecular Plant Physiology
- Zoran Nikoloski
- Institute of Biochemistry and Biology, University of Potsdam
- Bernhard O. Palsson
- Department of Bioengineering, University of California, San Diego
- Andrew E. Allen
- Microbial and Environmental Genomics, J. Craig Venter Institute
- DOI
- https://doi.org/10.1038/s41467-019-12407-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Here, using the diatom Phaeodactylum tricornutum as a model organism, the authors combine functional genomics, phylogenetics, and metabolic modeling to describe how diatoms might have functionally integrated nitrogen metabolism during evolution and how metabolic flux is regulated across cellular compartments
