Analysis on influencing factors for suspected allergic reactions to Xueshuantong Injection: based on real data from 7 medical institutions

Abstract

Objective To investigate the influencing factors of suspected allergic reactions caused by Xueshuantong Injection, and to provide reference for clinical rational drug use. Methods From June 2015 to February 2019, the medical records of the inpatients with the use of Xueshuantong Injection from 7 hospitals were collected. And 78 patients with suspected allergic reaction to the injection were obtained by prescription sequence analysis. Another 312 subjects sampled at 1:4 ratio of gender, age and inpatient department using propensity score matching were assigned into the control group. Conditional logistic regression was used to analyze the effects of solvent, allergy history, single dose and combination on suspected allergic reaction. Results There were no significant differences in the solvent, allergy history and single dose between the 2 groups (P>0.05). But statistical difference was seen in the combination of some drugs (P < 0.05), such as omeprazole (OR=3.28, P=0.007 6), pantoprazole (OR=3.103, P=0.002 8), mannitol (OR=4.017, P=0.000 4), tranexamic acid (OR=2.895, P=0.016 1), lidocaine (OR=4.401, P=0.001 3) and ambroxol (OR=3.607, P=0.003 6). Combination of the above drugs may increase the risk of allergic reactions. Conclusion The combination of Xueshuantong Injection with omeprazole, pantoprazole, mannitol, tranexamic acid, lidocaine and ambroxol may increase the risk of allergic reactions in the patients

Keywords

• xueshuantong injection
• drug allergy
• prescription sequence analysis
• nested case cohort study