Frontiers in Cell and Developmental Biology (Mar 2021)
Biophysical and Biochemical Cues of Biomaterials Guide Mesenchymal Stem Cell Behaviors
- Jianjun Li,
- Jianjun Li,
- Jianjun Li,
- Yufan Liu,
- Yufan Liu,
- Yijie Zhang,
- Yijie Zhang,
- Bin Yao,
- Bin Yao,
- Bin Yao,
- Enhejirigala,
- Enhejirigala,
- Enhejirigala,
- Enhejirigala,
- Zhao Li,
- Wei Song,
- Wei Song,
- Yuzhen Wang,
- Yuzhen Wang,
- Yuzhen Wang,
- Xianlan Duan,
- Xianlan Duan,
- Xianlan Duan,
- Xingyu Yuan,
- Xingyu Yuan,
- Xingyu Yuan,
- Xiaobing Fu,
- Xiaobing Fu,
- Xiaobing Fu,
- Sha Huang
Affiliations
- Jianjun Li
- Research Center for Tissue Repair and Regeneration, Medical Innovation Research Department and the Fourth Medical Center, Chinese PLA General Hospital, PLA Medical College, Beijing, China
- Jianjun Li
- PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, Chinese PLA General Hospital, PLA Medical College, Beijing, China
- Jianjun Li
- Department of General Surgery, The Sixth Medical Center, Chinese PLA General Hospital, Beijing, China
- Yufan Liu
- Research Center for Tissue Repair and Regeneration, Medical Innovation Research Department and the Fourth Medical Center, Chinese PLA General Hospital, PLA Medical College, Beijing, China
- Yufan Liu
- PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, Chinese PLA General Hospital, PLA Medical College, Beijing, China
- Yijie Zhang
- Research Center for Tissue Repair and Regeneration, Medical Innovation Research Department and the Fourth Medical Center, Chinese PLA General Hospital, PLA Medical College, Beijing, China
- Yijie Zhang
- PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, Chinese PLA General Hospital, PLA Medical College, Beijing, China
- Bin Yao
- Research Center for Tissue Repair and Regeneration, Medical Innovation Research Department and the Fourth Medical Center, Chinese PLA General Hospital, PLA Medical College, Beijing, China
- Bin Yao
- PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, Chinese PLA General Hospital, PLA Medical College, Beijing, China
- Bin Yao
- The Shenzhen Key Laboratory of Health Sciences and Technology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China
- Enhejirigala
- Research Center for Tissue Repair and Regeneration, Medical Innovation Research Department and the Fourth Medical Center, Chinese PLA General Hospital, PLA Medical College, Beijing, China
- Enhejirigala
- PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, Chinese PLA General Hospital, PLA Medical College, Beijing, China
- Enhejirigala
- College of Graduate, Tianjin Medical University, Tianjin, China
- Enhejirigala
- Institute of Basic Medical Research, Inner Mongolia Medical University, Hohhot, China
- Zhao Li
- Research Center for Tissue Repair and Regeneration, Medical Innovation Research Department and the Fourth Medical Center, Chinese PLA General Hospital, PLA Medical College, Beijing, China
- Wei Song
- Research Center for Tissue Repair and Regeneration, Medical Innovation Research Department and the Fourth Medical Center, Chinese PLA General Hospital, PLA Medical College, Beijing, China
- Wei Song
- PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, Chinese PLA General Hospital, PLA Medical College, Beijing, China
- Yuzhen Wang
- Research Center for Tissue Repair and Regeneration, Medical Innovation Research Department and the Fourth Medical Center, Chinese PLA General Hospital, PLA Medical College, Beijing, China
- Yuzhen Wang
- PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, Chinese PLA General Hospital, PLA Medical College, Beijing, China
- Yuzhen Wang
- Department of Burn and Plastic Surgery, Air Force Hospital of Chinese PLA Central Theater Command, Datong, China
- Xianlan Duan
- Research Center for Tissue Repair and Regeneration, Medical Innovation Research Department and the Fourth Medical Center, Chinese PLA General Hospital, PLA Medical College, Beijing, China
- Xianlan Duan
- PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, Chinese PLA General Hospital, PLA Medical College, Beijing, China
- Xianlan Duan
- School of Medicine, Nankai University, Tianjin, China
- Xingyu Yuan
- Research Center for Tissue Repair and Regeneration, Medical Innovation Research Department and the Fourth Medical Center, Chinese PLA General Hospital, PLA Medical College, Beijing, China
- Xingyu Yuan
- PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, Chinese PLA General Hospital, PLA Medical College, Beijing, China
- Xingyu Yuan
- School of Medicine, Nankai University, Tianjin, China
- Xiaobing Fu
- Research Center for Tissue Repair and Regeneration, Medical Innovation Research Department and the Fourth Medical Center, Chinese PLA General Hospital, PLA Medical College, Beijing, China
- Xiaobing Fu
- PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, Chinese PLA General Hospital, PLA Medical College, Beijing, China
- Xiaobing Fu
- Research Unit of Trauma Care, Tissue Repair and Regeneration, Chinese Academy of Medical Sciences, Beijing, China
- Sha Huang
- Research Center for Tissue Repair and Regeneration, Medical Innovation Research Department and the Fourth Medical Center, Chinese PLA General Hospital, PLA Medical College, Beijing, China
- DOI
- https://doi.org/10.3389/fcell.2021.640388
- Journal volume & issue
-
Vol. 9
Abstract
Mesenchymal stem cells (MSCs) have been widely used in the fields of tissue engineering and regenerative medicine due to their self-renewal capabilities and multipotential differentiation assurance. However, capitalizing on specific factors to precisely guide MSC behaviors is the cornerstone of biomedical applications. Fortunately, several key biophysical and biochemical cues of biomaterials that can synergistically regulate cell behavior have paved the way for the development of cell-instructive biomaterials that serve as delivery vehicles for promoting MSC application prospects. Therefore, the identification of these cues in guiding MSC behavior, including cell migration, proliferation, and differentiation, may be of particular importance for better clinical performance. This review focuses on providing a comprehensive and systematic understanding of biophysical and biochemical cues, as well as the strategic engineering of these signals in current scaffold designs, and we believe that integrating biophysical and biochemical cues in next-generation biomaterials would potentially help functionally regulate MSCs for diverse applications in regenerative medicine and cell therapy in the future.
Keywords
