Nature Communications (Jul 2020)
Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming
- Kenneth C. P. Cheung,
- Silvia Fanti,
- Claudio Mauro,
- Guosu Wang,
- Anitha S. Nair,
- Hongmei Fu,
- Silvia Angeletti,
- Silvia Spoto,
- Marta Fogolari,
- Francesco Romano,
- Dunja Aksentijevic,
- Weiwei Liu,
- Baiying Li,
- Lixin Cheng,
- Liwen Jiang,
- Juho Vuononvirta,
- Thanushiyan R. Poobalasingam,
- David M. Smith,
- Massimo Ciccozzi,
- Egle Solito,
- Federica M. Marelli-Berg
Affiliations
- Kenneth C. P. Cheung
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Silvia Fanti
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Claudio Mauro
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Guosu Wang
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Anitha S. Nair
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Hongmei Fu
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Silvia Angeletti
- Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome
- Silvia Spoto
- Internal Medicine Department, University campus Bio-Medico of Rome
- Marta Fogolari
- Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome
- Francesco Romano
- Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome
- Dunja Aksentijevic
- School of Biological and Chemical Sciences, Queen Mary University of London
- Weiwei Liu
- Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China
- Baiying Li
- School of Life Sciences, Centre for Cell & Developmental Biology and Partner State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong
- Lixin Cheng
- School of Life Sciences, Centre for Cell & Developmental Biology and Partner State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong
- Liwen Jiang
- School of Life Sciences, Centre for Cell & Developmental Biology and Partner State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong
- Juho Vuononvirta
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Thanushiyan R. Poobalasingam
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- David M. Smith
- AstraZeneca R&D, Cambridge Science Park
- Massimo Ciccozzi
- Unit of Medical Statistic and Molecular Epidemiology, University Campus Bio-Medico of Rome
- Egle Solito
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Federica M. Marelli-Berg
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- DOI
- https://doi.org/10.1038/s41467-020-17329-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
The mechanisms that restore endothelial barrier integrity following inflammation-induced breaching are incompletely understood. Here the authors show that the CD31 immune receptor contributes to reestablishing vascular integrity via its effects on endothelial cell metabolism.
