ANALYSIS OF THE COMPOSITION OF THE INTESTINAL MICROBIOCENOSIS IN PATIENTS WITH NON-SPECIFIC ULCEROUS CALITIS AND CROHN’S DISEASE

Abstract

The manifestations of dysbiotic syndrome were monitored in the setting of chronically inflammatory diseases among women and men of different ages. Significant imbalances were found in the direction of reducing the titers of symbionts – lactobacilli to 105 -0 CFU, bifidobacteria – 108 -107 , enterococci – 105 , typical Escherichia – 106 -103 and increasing the number of representatives of opportunistic enterobacteria to 108 -105 CFU, staphylococci – 106 -104 and fungi of the genus Candida – 106 -103 . A more significant manifestation of intestinal inflammation of the intestine in terms of fecal calprotectin in men compared with women was shown. In males of patients with nonspecific ulcerative colitis, the level of imbalance of intestinal microbiocenosis was more pronounced in contrast to females. The number of cases when there was a decrease in the number of the main representatives of normal flora exceeded in the male group than in the female group by an average of 12.5%. Also, the identification of opportunistic pathogenic microflora and fungi of the genus Candida in the titer of higher reference indicators was observed more often in men by an average of 7.8%. However, in Crohn’s disease, the frequency of registration of deviations in the titers of individual microbiota varied among women and men. The high incidence of chronic inflammatory bowel disease with the corresponding dysbiotic disorders was recorded in the group of people aged 20 to 44 years. All patients, regardless of their age, showed a significant decrease in lactobacillus titers. The number of cases when a decrease in the number of bifidobacteria was recorded, enterococci relative to the norm, exceeded among young people and was 41.4% and 27.6%, respectively. At the same time, the quantitative indices of colonization of opportunistic microorganisms of the digestive tract were higher in the elderly. The frequency of detection of yeast-like fungi of the genus Candida was at a high level in all the examined age groups and was 42.8% – 44.9%. It can be concluded that intestinal lesions caused by pathologies of nonspecific ulcerative colitis and Crohn’s disease play a leading role in the development of dysbacteriosis. The data obtained are the basis for studying the relationship between the depth of the pathogenesis of these diseases and the duration of dysbiotic disorders.

Keywords

• intestinal dysbiosis
• nonspecific ulcerative colitis
• Crohn’s disease
• fecal calprotectin.