Activated Peyer′s patch B cells sample antigen directly from M cells in the subepithelial dome

Rathan Joy Komban; Anneli Strömberg; Adi Biram; Jakob Cervin; Cristina Lebrero-Fernández; Neil Mabbott; Ulf Yrlid; Ziv Shulman; Mats Bemark; Nils Lycke

doi:10.1038/s41467-019-10144-w

Nature Communications (Jun 2019)

Activated Peyer′s patch B cells sample antigen directly from M cells in the subepithelial dome

Rathan Joy Komban,
Anneli Strömberg,
Adi Biram,
Jakob Cervin,
Cristina Lebrero-Fernández,
Neil Mabbott,
Ulf Yrlid,
Ziv Shulman,
Mats Bemark,
Nils Lycke

Affiliations

Rathan Joy Komban: Mucosal Immunobiology and Vaccine Center (MIVAC), Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg
Anneli Strömberg: Mucosal Immunobiology and Vaccine Center (MIVAC), Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg
Adi Biram: Department of Immunology, The Weizmann Institute of Science
Jakob Cervin: Mucosal Immunobiology and Vaccine Center (MIVAC), Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg
Cristina Lebrero-Fernández: Mucosal Immunobiology and Vaccine Center (MIVAC), Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg
Neil Mabbott: The Roslin Institute, Edinburgh University
Ulf Yrlid: Mucosal Immunobiology and Vaccine Center (MIVAC), Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg
Ziv Shulman: Department of Immunology, The Weizmann Institute of Science
Mats Bemark: Mucosal Immunobiology and Vaccine Center (MIVAC), Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg
Nils Lycke: Mucosal Immunobiology and Vaccine Center (MIVAC), Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg

DOI: https://doi.org/10.1038/s41467-019-10144-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

Read online

Gut lumen antigens must be continuously sampled by the immune system to maintain proper immune homeostasis. Here the authors show that activated CCR6+CCR1+GL7- gut B cells retrieve lumen antigens from specialized M cells and transfer them across the subepithelial dome in the Peyer’s patch to contribute to the maintenance of gut humoral immunity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal