Case Reports in Ophthalmology (Mar 2024)

Vogt-Koyanagi-Harada-Like Disease with Loss of Visual Acuity due to Sunitinib Treatment Restored after Switch in Therapy: A Case Report

  • Mechteld C.S. van Olden,
  • Yvonne de Jong-Hesse,
  • Tessa Vollebregt,
  • Stefanie de Groot,
  • Saskia A.C. Luelmo,
  • Marina Marinkovic

DOI
https://doi.org/10.1159/000536572
Journal volume & issue
Vol. 15, no. 1
pp. 184 – 188

Abstract

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Introduction: In this paper, we report a case of visual impairment during treatment with sunitinib in a patient with metastatic renal cell carcinoma. Methods: Retrospective chart review was used. Case Presentation: We describe a 74-year-old male with metastatic renal cell carcinoma who was treated with sunitinib and experienced severe loss of visual acuity due to serous retinal detachment and intraretinal fluid. Upon discontinuation of sunitinib, the retinal fluid resolved, and visual acuity was restored. Conclusion: Serous retinal detachment has been described as a side effect of sunitinib use. Discontinuing sunitinib promptly resolved the subretinal fluid collections and restored vision.

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