Biomedical Applications of Supramolecular Materials in the Controllable Delivery of Steroids

Yun Hao; Yun Hao; Feiyi Zhang; Feiyi Zhang; Shanshan Mo; Jinming Zhao; Jinming Zhao; Xiangdong Wang; Xiangdong Wang; Yan Zhao; Yan Zhao; Luo Zhang; Luo Zhang; Luo Zhang

doi:10.3389/fmolb.2021.700712

Frontiers in Molecular Biosciences (Jul 2021)

Biomedical Applications of Supramolecular Materials in the Controllable Delivery of Steroids

Yun Hao,
Yun Hao,
Feiyi Zhang,
Feiyi Zhang,
Shanshan Mo,
Jinming Zhao,
Jinming Zhao,
Xiangdong Wang,
Xiangdong Wang,
Yan Zhao,
Yan Zhao,
Luo Zhang,
Luo Zhang,
Luo Zhang

Affiliations

Yun Hao: Department of Otolaryngology Head and Neck Surgery, Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China
Yun Hao: Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China
Feiyi Zhang: Institute for Advanced Materials, Jiangsu University, Zhenjiang, China
Feiyi Zhang: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China
Shanshan Mo: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China
Jinming Zhao: Department of Otolaryngology Head and Neck Surgery, Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China
Jinming Zhao: Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China
Xiangdong Wang: Department of Otolaryngology Head and Neck Surgery, Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China
Xiangdong Wang: Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China
Yan Zhao: Department of Otolaryngology Head and Neck Surgery, Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China
Yan Zhao: Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China
Luo Zhang: Department of Otolaryngology Head and Neck Surgery, Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China
Luo Zhang: Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China
Luo Zhang: Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

DOI: https://doi.org/10.3389/fmolb.2021.700712
Journal volume & issue: Vol. 8

Abstract

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Glucocorticoids are a class of steroid hormones secreted from the adrenal glands. The strong anti-inflammatory effects make it be one of the most popular and versatile drugs available to treat chronic inflammatory diseases. Additionally, supramolecular materials have been widely exploited in drug delivery, due to their biocompatibility, tunability, and predictability. Thus, steroid-based supramolecular materials and the release of steroids have been applied in the treatment of inflammatory diseases. This mini-review summarized recent advances in supramolecular materials loaded with glucocorticoid drugs in terms of hydrophobic interactions, electrostatic interactions, hydrogen bonding, and π-π stackings. We also discussed and prospected the application of the glucocorticoid drugs-based supramolecular system on chronic rhinosinusitis, multifactorial inflammatory disease of the nasal and paranasal sinuses mucosal membranes. Overall, supramolecular materials can provide an alternative to traditional materials as a novel delivery platform in clinical practice.

Published in Frontiers in Molecular Biosciences

ISSN: 2296-889X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/molecular-biosciences

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