Nature Communications (Jul 2022)
Landscape of somatic alterations in large-scale solid tumors from an Asian population
- Liqun Wu,
- Herui Yao,
- Hui Chen,
- Aodi Wang,
- Kun Guo,
- Wenli Gou,
- Yanfei Yu,
- Xiang Li,
- Ming Yao,
- Shaohua Yuan,
- Fei Pang,
- Jinwei Hu,
- Lijuan Chen,
- Wenjin Liu,
- Jicheng Yao,
- Shuirong Zhang,
- Xiaowei Dong,
- Weifeng Wang,
- Jing Hu,
- Qi Ling,
- Songming Ding,
- Yan Wei,
- Qiang Li,
- Weichun Cao,
- Shuang Wang,
- Yang Di,
- Feiling Feng,
- Gang Zhao,
- Jian Zhang,
- Ling Huang,
- Jia Xu,
- Wangjun Yan,
- Zhongsheng Tong,
- Da Jiang,
- Tao Ji,
- Qiao Li,
- Ling Xu,
- Huiying He,
- Liang Shang,
- Jin Liu,
- Kefeng Wang,
- Duoguang Wu,
- Jingnan Shen,
- Ye Liu,
- Ting Zhang,
- Chaojie Liang,
- Yusheng Wang,
- Yanhong Shang,
- Jianji Guo,
- Guanbiao Liang,
- Shifeng Xu,
- Junfeng Liu,
- Kai Wang,
- Minghui Wang
Affiliations
- Liqun Wu
- Department of Hepatobiliary Surgery, Affiliated Hospital of Qingdao University
- Herui Yao
- Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Medical Oncology, Breast Tumor Center and Phase I Clinical Trial Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Hui Chen
- Shanghai OrigiMed Co., Ltd
- Aodi Wang
- Shanghai OrigiMed Co., Ltd
- Kun Guo
- Liver Cancer Institute, Zhongshan Hospital, Fudan University
- Wenli Gou
- Department of Obstetrics and Gynecology, First Affiliated Hospital of Xi’an Jiao Tong University
- Yanfei Yu
- Shanghai OrigiMed Co., Ltd
- Xiang Li
- Shanghai OrigiMed Co., Ltd
- Ming Yao
- Shanghai OrigiMed Co., Ltd
- Shaohua Yuan
- Shanghai OrigiMed Co., Ltd
- Fei Pang
- Shanghai OrigiMed Co., Ltd
- Jinwei Hu
- Shanghai OrigiMed Co., Ltd
- Lijuan Chen
- Shanghai OrigiMed Co., Ltd
- Wenjin Liu
- Shanghai OrigiMed Co., Ltd
- Jicheng Yao
- Shanghai OrigiMed Co., Ltd
- Shuirong Zhang
- Shanghai OrigiMed Co., Ltd
- Xiaowei Dong
- Shanghai OrigiMed Co., Ltd
- Weifeng Wang
- Shanghai OrigiMed Co., Ltd
- Jing Hu
- Department of Medical Oncology, The First People’s Hospital of Yunnan Province
- Qi Ling
- Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University
- Songming Ding
- Department of Hepatobiliary and Pancreatic Surgery, Shu Lan (Hangzhou) Hospital
- Yan Wei
- Department of Oncology, Guigang City People’s Hospital, The Eighth Affiliated Hospital of Guangxi Medical University
- Qiang Li
- Department of Hepatobiliary Surgery, Affiliated Hospital of North Sichuan Medical University
- Weichun Cao
- Department of Gynecologic Oncology, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University
- Shuang Wang
- Department of Pathology, School of Basic Medical Sciences, Southern Medical University
- Yang Di
- Department of Pancreatic Surgery, Huashan Hospital, Fudan University
- Feiling Feng
- Department of Biliary Surgery, Shanghai Eastern Hepatobiliary Surgery Hospital
- Gang Zhao
- Department of Pathology, Tianjin Medical University Cancer Institute and Hospital
- Jian Zhang
- Department of General Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Ling Huang
- Department of Gastrointestinal Oncology, Huifuxi Branch of Guangdong Provincial People’s Hospital
- Jia Xu
- Department of Emergency, The First Affiliated Hospital, Sun Yat-sen University
- Wangjun Yan
- Department of Musculoskeletal Surgery, Shanghai Cancer Center, Fudan University
- Zhongsheng Tong
- Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital
- Da Jiang
- Department of Oncology, Fourth Hospital of Hebei Medical University
- Tao Ji
- Musculoskeletal Tumor Center, Beijing Key Laboratory for Musculoskeletal Tumors, People’s Hospital, Peking University
- Qiao Li
- National Cancer Center/ Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Ling Xu
- Breast Disease Center, Peking University First Hospital
- Huiying He
- Department of Pathology, School of Basic Medical Sciences, Third Hospital, Peking University
- Liang Shang
- Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University
- Jin Liu
- Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University
- Kefeng Wang
- Department of Thoracic Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University
- Duoguang Wu
- Department of Thoracic Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University
- Jingnan Shen
- Department of Musculoskeletal Oncology, First Affiliated Hospital, Sun Yat-sen University
- Ye Liu
- Department of Pathology, The Fifth Affiliated Hospital, Sun Yat-sen University
- Ting Zhang
- Department of Bone Marrow, The First Affiliated Hospital, College of Medicine, Zhejiang University
- Chaojie Liang
- Department of General Surgery, The First Hospital of Shanxi Medical University
- Yusheng Wang
- Department of Digestive, Shanxi Provincial Cancer Hospital
- Yanhong Shang
- Department of Medical Oncology, The Affiliated Hospital, Hebei University
- Jianji Guo
- Department of Thoracic Surgery, First Affiliated Hospital of Guangxi Medical University
- Guanbiao Liang
- Department of Thoracic Surgery, First Affiliated Hospital of Guangxi Medical University
- Shifeng Xu
- Department of Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong University
- Junfeng Liu
- Department of Thoracic Surgery, Fourth Hospital of Hebei Medical University
- Kai Wang
- Shanghai OrigiMed Co., Ltd
- Minghui Wang
- Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Thoracic Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- DOI
- https://doi.org/10.1038/s41467-022-31780-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
Understanding the mutation landscape of cancer may enable the development of more targeted therapies. Here, the authors sequence a panel of genes in a large Asian cohort and compare to American cohorts and find 64% of the Asian patients have actionable mutations.
