MITOCHONDRIAL CHANGES IN THE KIDNEY AND LIVER OT MICE INDUCED BY OCHRATOXIN A - AN ELECTRONMICROSCOPIC STUDY

Abstract

Ultrastructural changes of renal and hepatic mitochondria in mice induced by OA were studied. Mitrochondria exhibited diverse morphological aberrations. The outer mitochondria) membranes, cristae and matrix were affected. The changes were more prominent in the proximal and distal convoluted tubules of kidney. In the liver, besides the mitochondrial changes, there was proliferation of SER. An increase in the peroxisomes was observed in the kidney and liver. The morphological aberrations seen in die mitochondria indicate that OA has a direct toxic action on the mitochondria causing aberrations of mitochondrial fuction resultnig in metabolic derangement in the cell.